The base excision repair machinery protects DNA in cells from the damaging effects of
oxidation, alkylation, and deamination; it is specialized to fix single-base damage in the form …

Reactive oxygen species continuously assault the structure of DNA resulting in oxidation
and fragmentation of the nucleobases. Both oxidative DNA damage itself and its repair …

Thymine DNA glycosylase (TDG) excises T from G· T mispairs and is thought to initiate base
excision repair (BER) of deaminated 5-methylcytosine (mC). Recent studies show that TDG …

Base excision repair is the system used from bacteria to man to remove the tens of
thousands of endogenous DNA damages produced daily in each human cell. Base excision …

Human thymine DNA glycosylase (hTDG) efficiently excises 5-carboxylcytosine (5caC), a
key oxidation product of 5-methylcytosine in genomic DNA, in a recently discovered cytosine …

The base excision repair (BER) pathway is a frontline defender of genomic integrity and
plays a central role in epigenetic regulation through its involvement in the erasure of 5 …

A multitude of functions have evolved around cytosine within DNA, endowing the base with
physiological significance beyond simple information storage. This versatility arises from …

DNA glycosylases safeguard the genome by locating and excising a diverse array of
aberrant nucleobases created from oxidation, alkylation, and deamination of DNA. Since the …

A fundamental and shared process in all forms of life is the use of DNA glycosylase enzymes
to excise rare damaged bases from genomic DNA. Without such enzymes, the highly …

The mammalian thymine DNA glycosylase (TDG) is implicated in active DNA demethylation
via the base excision repair pathway. TDG excises the mismatched base from G: X …