Molecular mechanisms of antibiotic resistance revisited

EM Darby, E Trampari, P Siasat, MS Gaya… - Nature Reviews …, 2023 - nature.com
Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …

Metallo-β-lactamases in the age of multidrug resistance: from structure and mechanism to evolution, dissemination, and inhibitor design

G Bahr, LJ Gonzalez, AJ Vila - Chemical reviews, 2021 - ACS Publications
Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

How to enter a bacterium: bacterial porins and the permeation of antibiotics

JD Prajapati, U Kleinekathöfer… - Chemical …, 2021 - ACS Publications
Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …

Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria

J Vergalli, IV Bodrenko, M Masi, L Moynié… - Nature Reviews …, 2020 - nature.com
Gram-negative bacteria and their complex cell envelope, which comprises an outer
membrane and an inner membrane, are an important and attractive system for studying the …

Distinct Roles of Outer Membrane Porins in Antibiotic Resistance and Membrane Integrity in Escherichia coli

U Choi, CR Lee - Frontiers in microbiology, 2019 - frontiersin.org
A defining characteristic of Gram-negative bacteria is the presence of an outer membrane,
which functions as an additional barrier inhibiting the penetration of toxic chemicals, such as …

Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance

L Fernández, REW Hancock - Clinical microbiology reviews, 2012 - Am Soc Microbiol
The substantial use of antibiotics in the clinic, combined with a dearth of new antibiotic
classes, has led to a gradual increase in the resistance of bacterial pathogens to these …

Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria

M Masi, M Réfregiers, KM Pos - Nature microbiology, 2017 - nature.com
Researchers, clinicians and governments all recognize antimicrobial resistance as a serious
and growing threat worldwide. New antimicrobials are urgently needed, especially for …

Understanding antibiotic resistance via outer membrane permeability

I Ghai, S Ghai - Infection and drug resistance, 2018 - Taylor & Francis
Collective antibiotic drug resistance is a global threat, especially with respect to Gram-
negative bacteria. The low permeability of the bacterial outer cell wall has been identified as …

Outer membrane porins contribute to antimicrobial resistance in gram-negative bacteria

G Zhou, Q Wang, Y Wang, X Wen, H Peng, R Peng… - Microorganisms, 2023 - mdpi.com
Gram-negative bacteria depend on their cell membranes for survival and environmental
adaptation. They contain two membranes, one of which is the outer membrane (OM), which …

The binding of antibiotics in OmpF porin

BK Ziervogel, B Roux - Structure, 2013 - cell.com
The structure of OmpF porin in complex with three common antibiotics (zwitterionic
ampicillin, anionic ertapenem, and di-anionic carbenicillin) was determined using X-ray …