Polymeric long-acting drug delivery systems (LADDS) for treatment of chronic diseases: Inserts, patches, wafers, and implants

H Abdelkader, Z Fathalla, A Seyfoddin… - Advanced drug delivery …, 2021 - Elsevier
Non-oral long-acting drug delivery systems (LADDS) encompass a range of technologies for
precisely delivering drug molecules into target tissues either through the systemic circulation …

[HTML][HTML] Site-specific targeted drug delivery systems for the treatment of inflammatory bowel disease

X Li, C Lu, Y Yang, C Yu, Y Rao - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Inflammatory bowel disease (IBD) includes Crohn's disease and ulcerative colitis and
manifests as a complex and dysregulated immune response. To date, there is no cure for …

Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease

S Zhang, L Kang, S Hu, J Hu, Y Fu, Y Hu… - International Journal of …, 2021 - Elsevier
A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific
distribution of drugs during long-term treatment. Despite its effectiveness as an anti …

A probiotic spore‐based oral autonomous nanoparticles generator for cancer therapy

Q Song, C Zheng, J Jia, H Zhao, Q Feng… - Advanced …, 2019 - Wiley Online Library
Spores, the dormant life forms of probiotics, can germinate to metabolically active vegetative
cells with the disintegration of their hydrophobic protein coat in the intestinal …

Local delivery of macromolecules to treat diseases associated with the colon

A Bak, M Ashford, DJ Brayden - Advanced drug delivery reviews, 2018 - Elsevier
Current treatments for intestinal diseases including inflammatory bowel diseases, irritable
bowel syndrome, and colonic bacterial infections are typically small molecule oral dosage …

Oral delivery of curcumin via multi-bioresponsive polyvinyl alcohol and guar gum based double-membrane microgels for ulcerative colitis therapy

Y Hu, S Zhang, Z Wen, H Fu, J Hu, X Ye, L Kang… - International Journal of …, 2022 - Elsevier
Anti-inflammatory drugs for ulcerative colitis (UC) treatment should specifically penetrate
and accumulate in the colon tissue. Herein, a multi-bioresponsive anti-inflammatory drug …

Macrophages-targeting mannosylated nanoparticles based on inulin for the treatment of inflammatory bowel disease (IBD)

Q Sun, M Arif, Z Chi, G Li, CG Liu - International Journal of Biological …, 2021 - Elsevier
In the present experimental series, we have developed a novel nanocomposite to target
activated macrophages in the colon with real time imaging and therapeutic capabilities. This …

The potential of Fe‐based magnetic nanomaterials for the agriculture sector

J Le Wee, MC Law, YS Chan, SY Choy… - …, 2022 - Wiley Online Library
Iron‐based magnetic nanoparticles (MNPs) have been studied extensively for the past few
decades. They have been applied in various applications, particularly in the biomedical …

In Vitro Methods to Study Colon Release: State of the Art and An Outlook on New Strategies for Better In-Vitro Biorelevant Release Media

M Wahlgren, M Axenstrand, Å Håkansson, A Marefati… - Pharmaceutics, 2019 - mdpi.com
The primary focus of this review is a discussion regarding in vitro media for colon release,
but we also give a brief overview of colon delivery and the colon microbiota as a baseline for …

Site-directed non-covalent polymer-drug complexes for inflammatory bowel disease (IBD): formulation development, characterization and pharmacological evaluation

SS Kesharwani, R Ahmad, MA Bakkari… - Journal of Controlled …, 2018 - Elsevier
Abstract Inflammatory Bowel Diseases (IBD) is a debilitating condition that affects~ 70,000
new people every year and has been described as “an expensive disease with no known …