The neurobiological basis of human aggression: a review on genetic and epigenetic mechanisms

R Waltes, AG Chiocchetti… - American Journal of …, 2016 - Wiley Online Library
Aggression is an evolutionary conserved behavior present in most species including
humans. Inadequate aggression can lead to long‐term detrimental personal and societal …

Behavioral and psychological symptoms in Alzheimer's disease

XL Li, N Hu, MS Tan, JT Yu… - BioMed research …, 2014 - Wiley Online Library
Neuropsychiatric symptoms (NPS) such as depression, apathy, aggression, and psychosis
are now recognized as core features of Alzheimer's disease (AD), and there is a general …

Pimavanserin, a serotonin2A receptor inverse agonist, for the treatment of Parkinson's disease psychosis

HY Meltzer, R Mills, S Revell, H Williams… - …, 2010 - nature.com
Psychotic symptoms occur in up to 40% of patients with Parkinson's disease (PD). Clozapine
and quetiapine, two atypical antipsychotic drugs, at doses markedly lower than those …

Genetics of aggression

RRH Anholt, TFC Mackay - Annual review of genetics, 2012 - annualreviews.org
Aggression mediates competition for food, mating partners, and habitats and, among social
animals, establishes stable dominance hierarchies. In humans, abnormal aggression is a …

[HTML][HTML] Small nucleolar RNAs in plasma extracellular vesicles and their discriminatory power as diagnostic biomarkers of Alzheimer's disease

NF Fitz, J Wang, MI Kamboh, R Koldamova… - Neurobiology of …, 2021 - Elsevier
The clinical diagnosis of Alzheimer's disease, at its early stage, remains a difficult task.
Advanced imaging technologies and laboratory assays to detect Aβ peptides Aβ42 and …

Efficacy of serotonergic antidepressant treatment for the neuropsychiatric symptoms and agitation in dementia: a systematic review and meta-analysis

TW Hsu, B Stubbs, CS Liang, TY Chen, TC Yeh… - Ageing Research …, 2021 - Elsevier
Objective Serotonergic dysfunction may be involved in the etiology of overall
neuropsychiatric symptoms (NPS) and agitation in patients with dementia; therefore, we aim …

APOE-4 genotype and neurophysiological vulnerability to Alzheimer's and cognitive aging

S Bookheimer, A Burggren - Annual review of clinical …, 2009 - annualreviews.org
Many years before receiving a clinical diagnosis of Alzheimer's disease (AD), patients
experience evidence of cognitive decline. Recent studies using a variety of brain imaging …

NMDA neurotransmission dysfunction in behavioral and psychological symptoms of Alzheimer's disease

YJ Huang, CH Lin, HY Lane… - Current …, 2012 - ingentaconnect.com
Dementia has become an all-important disease because the population is aging rapidly and
the cost of health care associated with dementia is ever increasing. In addition to cognitive …

Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT) 2A receptors in the …

N Egashira, K Iwasaki, A Ishibashi, K Hayakawa… - Progress in Neuro …, 2008 - Elsevier
Behavioral and psychological symptoms of dementia (BPSD) are commonly seen in patients
with Alzheimer's disease (AD) and other forms of senile dementia. BPSD have a serious …

Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease

A Monji, M Takita, T Samejima, T Takaishi… - Progress in Neuro …, 2009 - Elsevier
OBJECTIVE: The aim of this study was to investigate the effects of yokukansan (YKS) on the
behavioral and psychological symptoms of dementia (BPSD) in elderly patients with …