The clinical importance of interstitial lung abnormality (ILA) is increasingly recognized. In
July 2020, the Fleischner Society published a position paper about ILA. The purposes of this …

The Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) study,
which began in 2007, is an ongoing multicenter observational cohort study of more than …

The term interstitial lung abnormalities refers to specific CT findings that are potentially
compatible with interstitial lung disease in patients without clinical suspicion of the disease …

The Biomarkers Definitions Working Group defines a clinical endpoint as a variable that
reflects how a patient feels, functions, or survives (5, 6). The past 3 decades of IPF clinical …

Subtle interstitial changes in the lung parenchyma of smokers, known as Interstitial Lung
Abnormalities (ILA), have been associated with clinical outcomes, including mortality, even …

Idiopathic pulmonary fibrosis (IPF) is a chronic, debilitating, fibrotic lung disease leading to
respiratory failure and ultimately to death. Being the prototype of interstitial lung diseases …

Rationale: Cor pulmonale (right ventricular [RV] dilation) and cor pulmonale parvus (RV
shrinkage) are both described in chronic obstructive pulmonary disease (COPD). The …

Rationale: Although studies have evaluated emphysema and fibrotic interstitial lung
abnormality individually, less is known about their combined progression. Objectives: To …

Rationale: Interstitial lung abnormalities (ILAs) are being increasingly identified in clinical
practice. In particular, for subpleural nonfibrotic ILAs, the risk of progression over time and …

Fibrotic interstitial lung diseases (ILDs) have a high mortality rate with an unpredictable
disease course and clinical features that frequently overlap. Recent data indicate important …