Optogenetics at the presynapse
Optogenetic actuators enable highly precise spatiotemporal interrogation of biological
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …
Mechanisms underlying gain modulation in the cortex
KA Ferguson, JA Cardin - Nature Reviews Neuroscience, 2020 - nature.com
Cortical gain regulation allows neurons to respond adaptively to changing inputs. Neural
gain is modulated by internal and external influences, including attentional and arousal …
gain is modulated by internal and external influences, including attentional and arousal …
Thermal constraints on in vivo optogenetic manipulations
A key assumption of optogenetics is that light only affects opsin-expressing neurons.
However, illumination invariably heats tissue, and many physiological processes are …
However, illumination invariably heats tissue, and many physiological processes are …
Different neuronal activity patterns induce different gene expression programs
KM Tyssowski, NR DeStefino, JH Cho, CJ Dunn… - Neuron, 2018 - cell.com
A vast number of different neuronal activity patterns could each induce a different set of
activity-regulated genes. Mapping this coupling between activity pattern and gene induction …
activity-regulated genes. Mapping this coupling between activity pattern and gene induction …
The ins and outs of the striatum: role in drug addiction
Addiction is a chronic relapsing disorder characterized by the loss of control over drug
intake, high motivation to obtain the drug, and a persistent craving for the drug …
intake, high motivation to obtain the drug, and a persistent craving for the drug …
State-of-the-art MEMS and microsystem tools for brain research
JP Seymour, F Wu, KD Wise, E Yoon - Microsystems & …, 2017 - nature.com
Mapping brain activity has received growing worldwide interest because it is expected to
improve disease treatment and allow for the development of important neuromorphic …
improve disease treatment and allow for the development of important neuromorphic …
Differential attentional control mechanisms by two distinct noradrenergic coeruleo-frontal cortical pathways
The attentional control of behavior is a higher-order cognitive function that operates through
attention and response inhibition. The locus coeruleus (LC), the main source of …
attention and response inhibition. The locus coeruleus (LC), the main source of …
Animal functional magnetic resonance imaging: trends and path toward standardization
Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive
window into brain activity. A collection of associated methods aims to replicate observations …
window into brain activity. A collection of associated methods aims to replicate observations …
Towards the optical cochlear implant: optogenetic approaches for hearing restoration
Cochlear implants (CI s) are considered the most successful neuroprosthesis as they enable
speech comprehension in the majority of half a million CI users suffering from sensorineural …
speech comprehension in the majority of half a million CI users suffering from sensorineural …
Dissecting the role of subtypes of gastrointestinal vagal afferents
Gastrointestinal (GI) vagal afferents convey sensory signals from the GI tract to the brain.
Numerous subtypes of GI vagal afferent have been identified but their individual roles in gut …
Numerous subtypes of GI vagal afferent have been identified but their individual roles in gut …