Optogenetics at the presynapse

BR Rost, J Wietek, O Yizhar, D Schmitz - Nature neuroscience, 2022 - nature.com
Optogenetic actuators enable highly precise spatiotemporal interrogation of biological
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …

Mechanisms underlying gain modulation in the cortex

KA Ferguson, JA Cardin - Nature Reviews Neuroscience, 2020 - nature.com
Cortical gain regulation allows neurons to respond adaptively to changing inputs. Neural
gain is modulated by internal and external influences, including attentional and arousal …

Thermal constraints on in vivo optogenetic manipulations

SF Owen, MH Liu, AC Kreitzer - Nature neuroscience, 2019 - nature.com
A key assumption of optogenetics is that light only affects opsin-expressing neurons.
However, illumination invariably heats tissue, and many physiological processes are …

Different neuronal activity patterns induce different gene expression programs

KM Tyssowski, NR DeStefino, JH Cho, CJ Dunn… - Neuron, 2018 - cell.com
A vast number of different neuronal activity patterns could each induce a different set of
activity-regulated genes. Mapping this coupling between activity pattern and gene induction …

The ins and outs of the striatum: role in drug addiction

LM Yager, AF Garcia, AM Wunsch, SM Ferguson - Neuroscience, 2015 - Elsevier
Addiction is a chronic relapsing disorder characterized by the loss of control over drug
intake, high motivation to obtain the drug, and a persistent craving for the drug …

State-of-the-art MEMS and microsystem tools for brain research

JP Seymour, F Wu, KD Wise, E Yoon - Microsystems & …, 2017 - nature.com
Mapping brain activity has received growing worldwide interest because it is expected to
improve disease treatment and allow for the development of important neuromorphic …

Differential attentional control mechanisms by two distinct noradrenergic coeruleo-frontal cortical pathways

A Bari, S Xu, M Pignatelli, D Takeuchi… - Proceedings of the …, 2020 - National Acad Sciences
The attentional control of behavior is a higher-order cognitive function that operates through
attention and response inhibition. The locus coeruleus (LC), the main source of …

Animal functional magnetic resonance imaging: trends and path toward standardization

F Mandino, DH Cerri, CM Garin, M Straathof… - Frontiers in …, 2020 - frontiersin.org
Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive
window into brain activity. A collection of associated methods aims to replicate observations …

Towards the optical cochlear implant: optogenetic approaches for hearing restoration

A Dieter, D Keppeler, T Moser - EMBO molecular medicine, 2020 - embopress.org
Cochlear implants (CI s) are considered the most successful neuroprosthesis as they enable
speech comprehension in the majority of half a million CI users suffering from sensorineural …

Dissecting the role of subtypes of gastrointestinal vagal afferents

YB Wang, G De Lartigue, AJ Page - Frontiers in Physiology, 2020 - frontiersin.org
Gastrointestinal (GI) vagal afferents convey sensory signals from the GI tract to the brain.
Numerous subtypes of GI vagal afferent have been identified but their individual roles in gut …