Lung MRI with hyperpolarised gases: current & future clinical perspectives

NJ Stewart, LJ Smith, HF Chan… - The British Journal of …, 2022 - academic.oup.com
The use of pulmonary MRI in a clinical setting has historically been limited. Whilst CT
remains the gold-standard for structural lung imaging in many clinical indications, technical …

Time to get serious about the detection and monitoring of early lung disease in cystic fibrosis

KJ Bayfield, TA Douglas, T Rosenow, JC Davies… - Thorax, 2021 - thorax.bmj.com
Structural and functional defects within the lungs of children with cystic fibrosis (CF) are
detectable soon after birth and progress throughout preschool years often without overt …

129Xe and Free‐Breathing 1H Ventilation MRI in Patients With Cystic Fibrosis: A Dual‐Center Study

H Marshall, A Voskrebenzev, LJ Smith… - Journal of Magnetic …, 2023 - Wiley Online Library
Background Free‐breathing 1H ventilation MRI shows promise but only single‐center
validation has yet been performed against methods which directly image lung ventilation in …

Inter‐and intravisit repeatability of free‐breathing MRI in pediatric cystic fibrosis lung disease

S Munidasa, B Zanette, M Couch… - Magnetic …, 2023 - Wiley Online Library
Purpose The purpose of this study is to assess the intra‐and interscan repeatability of free‐
breathing phase‐resolved functional lung (PREFUL) MRI in stable pediatric cystic fibrosis …

Lung Function in Patients with Cystic Fibrosis before and during CFTR-Modulator Therapy Using 3D Ultrashort Echo Time MRI

JF Heidenreich, PJ Kuhl, JP Grunz, R Hendel, C Metz… - Radiology, 2023 - pubs.rsna.org
Background The triple combination of the cystic fibrosis transmembrane regulator (CFTR)
modulators elexacaftor, tezacaftor, and ivacaftor (hereafter, elexacaftor/tezacaftor/ivacaftor) …

MR imaging of the airways

J Biederer - The British Journal of Radiology, 2023 - academic.oup.com
The need for airway imaging is defined by the limited sensitivity of common clinical tests like
spirometry, lung diffusion (DLCO) and blood gas analysis to early changes of peripheral …

Improving Xenon‐129 lung ventilation image SNR with deep‐learning based image reconstruction

NJ Stewart, J de Arcos, AM Biancardi… - Magnetic …, 2024 - Wiley Online Library
Purpose To evaluate the feasibility and utility of a deep learning (DL)‐based reconstruction
for improving the SNR of hyperpolarized 129Xe lung ventilation MRI. Methods 129Xe lung …

Image Phenotyping of Preterm-Born Children Using Hyperpolarized 129Xe Lung Magnetic Resonance Imaging and Multiple-Breath Washout

HF Chan, LJ Smith, AM Biancardi, J Bray… - American Journal of …, 2023 - atsjournals.org
Rationale: Preterm birth is associated with low lung function in childhood, but little is known
about the lung microstructure in childhood. Objectives: We assessed the differential …

Monitoring early stage lung disease in cystic fibrosis

C Nissenbaum, G Davies, A Horsley… - Current Opinion in …, 2020 - journals.lww.com
Monitoring early stage lung disease in cystic fibrosis : Current Opinion in Pulmonary
Medicine Monitoring early stage lung disease in cystic fibrosis : Current Opinion in …

The impact of segmentation on whole‐lung functional MRI quantification: repeatability and reproducibility from multiple human observers and an artificial neural …

C Willers, G Bauman, S Andermatt… - Magnetic resonance …, 2021 - Wiley Online Library
Purpose To investigate the repeatability and reproducibility of lung segmentation and their
impact on the quantitative outcomes from functional pulmonary MRI. Additionally, to validate …