Abnormal choline metabolism is emerging as a metabolic hallmark that is associated with
oncogenesis and tumour progression. Following transformation, the modulation of enzymes …

It is well established that lipid metabolism is drastically altered during tumor development
and response to therapy. Choline kinase alpha (ChoKα) is a key mediator of these changes …

Background Mutations of the isocitrate dehydrogenase 1 and 2 gene (IDH1/2) were initially
thought to enhance cancer cell survival and proliferation by promoting the Warburg effect …

Gain-of-function mutations of the isocitrate dehydrogenase 1 (IDH1) gene are among the
most prevalent in low-grade gliomas and secondary glioblastoma. They lead to intracellular …

Mutations of the isocitrate dehydrogenase 1 (IDH1) gene are among the most prevalent in
low-grade glioma and secondary glioblastoma, represent an early pathogenic event, and …

Chemical exchange saturation transfer (CEST) is an MRI contrast mechanism that detects
the exchange of protons from distinct hydroxyl, amine, and amide groups to tissue water …

Abstract The phosphatidylinositol-3-kinase/Akt/mammalian target of rapamycin
(PI3K/Akt/mTOR) signaling pathway is activated in more than88% of glioblastomas (GBM) …

Recent findings show that exposure to temozolomide (TMZ), a DNA-damaging drug used to
treat glioblastoma (GBM), can suppress the conversion of pyruvate to lactate. To understand …

This review provides a summary of recent discoveries in choline transport and the proteins
mediating it with a specific focus on the choline transporter-like proteins (CTL)/solute carriers …

Glioblastoma multiforme (GBM) is the most common form of malignant glioma, characterized
by unpredictable clinical behaviors that suggest distinct molecular subtypes. With the tumor …