Major mechanisms for the recognition of pathogens by immune cells have evolved to
employ classical and non-classical major histocompatibility complex class I (MHC I) …

Efforts are being made worldwide to understand the immune response to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the coronavirus …

An individual's T cell repertoire dynamically encodes their pathogen exposure history. To
determine whether pathogen exposure signatures can be identified by documenting public T …

The now-famous term “restriction” derived from experiments in which T cells from Donor A
failed to recognize Ags presented by cells from Donor B. Restriction results from interdonor …

Abstract Background Middle East Respiratory Syndrome Coronavirus (MERS-COV) is the
main cause of lung and kidney infections in developing countries such as Saudi Arabia and …

Ag presentation on HLA molecules plays a central role in infectious diseases and tumor
immunology. To date, large-scale identification of (neo-) Ags from DNA sequencing data has …

Human T cell receptors (TCRs) are critical for mediating immune responses to pathogens
and tumors and regulating self-antigen recognition. Yet, variations in the genes encoding …

Chimeric antigen receptor (CAR) T cells have emerged as a promising class of therapeutic
agents, generating remarkable responses in the clinic for a subset of human cancers. One …

Immunotherapies such as chimeric antigen receptor (CAR) T cells and bispecific antibodies
redirect healthy T cells to kill cancer cells expressing the target antigen. The pan-B cell …

Recent deep sequencing studies on T-cell receptor (TCR) repertoire have provided robust
data to characterize diversity of T-cell immune responsiveness to a wide variety of peptide …