Recent advances in microfluidic technologies for cell-to-cell interaction studies

M Rothbauer, H Zirath, P Ertl - Lab on a Chip, 2018 - pubs.rsc.org
Microfluidic cell cultures are ideally positioned to become the next generation of in vitro
diagnostic tools for biomedical research, where key biological processes such as cell …

Expanding CAR-T cell immunotherapy horizons through microfluidics

H Kim, S Kim, H Lim, AJ Chung - Lab on a Chip, 2024 - pubs.rsc.org
Chimeric antigen receptor (CAR)-T cell therapies have revolutionized cancer treatment,
particularly in hematological malignancies. However, their application to solid tumors is …

Characterization of four functional biocompatible pressure-sensitive adhesives for rapid prototyping of cell-based lab-on-a-chip and organ-on-a-chip systems

SRA Kratz, C Eilenberger, P Schuller, B Bachmann… - Scientific reports, 2019 - nature.com
In the advent of affordable photo-and soft-lithography using polydimethylsiloxane (PDMS),
low cost multi-step microfabrication methods have become available to a broad scientific …

Every breath you take: non-invasive real-time oxygen biosensing in two-and three-dimensional microfluidic cell models

H Zirath, M Rothbauer, S Spitz, B Bachmann… - Frontiers in …, 2018 - frontiersin.org
Knowledge on the availability of dissolved oxygen inside microfluidic cell culture systems is
vital for recreating physiological-relevant microenvironments and for providing reliable and …

Monitoring tissue-level remodelling during inflammatory arthritis using a three-dimensional synovium-on-a-chip with non-invasive light scattering biosensing

M Rothbauer, G Höll, C Eilenberger, SRA Kratz… - Lab on a Chip, 2020 - pubs.rsc.org
Rheumatoid arthritis is a chronic, systemic joint disease in which an autoimmune response
translates into an inflammatory attack resulting in joint damage, disability and decreased …

A lab-on-a-chip system with an embedded porous membrane-based impedance biosensor array for nanoparticle risk assessment on placental Bewo trophoblast cells

P Schuller, M Rothbauer, SRA Kratz, G Höll… - Sensors and Actuators B …, 2020 - Elsevier
The human placenta is a unique organ serving as the lung, gut, liver, and kidney of the fetus,
mediating the exchange of different endogenous as well as exogenous substances and …

Bridging the academic–industrial gap: application of an oxygen and pH sensor-integrated lab-on-a-chip in nanotoxicology

H Zirath, S Spitz, D Roth, T Schellhorn, M Rothbauer… - Lab on a Chip, 2021 - pubs.rsc.org
Translation of advanced cell-based assays exhibiting a higher degree of automation,
miniaturization, and integration of complementary sensing functions is mainly limited by the …

Microfluidic technologies for immunotherapy studies on solid tumours

K Paterson, S Zanivan, R Glasspool, SB Coffelt… - Lab on a Chip, 2021 - pubs.rsc.org
Immunotherapy is a powerful and targeted cancer treatment that exploits the body's immune
system to attack and eliminate cancerous cells. This form of therapy presents the possibility …

Shining a light on cancer—Photonics in microfluidic tumor modeling and biosensing

CF Guimarães, D Cruz‐Moreira… - Advanced …, 2023 - Wiley Online Library
Microfluidic platforms represent a powerful approach to miniaturizing important
characteristics of cancers, improving in vitro testing by increasing physiological relevance …

Understanding organotropism in cancer metastasis using microphysiological systems

J Ko, J Song, Y Lee, N Choi, HN Kim - Lab on a Chip, 2024 - pubs.rsc.org
Cancer metastasis, the leading cause of cancer-related deaths, remains a complex
challenge in medical science. Stephen Paget's “seed and soil theory” introduced the …