Targeting aberrant amino acid metabolism for pancreatic cancer therapy: Opportunities for nanoparticles

X Zang, K Lei, J Wang, R Gong, C Gao, Z Jing… - Chemical Engineering …, 2024 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal malignancies with
insidious initiation and early metastasis. The autonomous reprogramming of amino acid …

The Mechanism of Cancer-Depression Comorbidity

JW Huang, CA Cao, WH Zheng, CR Jia, X Liu, SQ Gao… - Neuroscience, 2024 - Elsevier
Cancer and depression are closely interrelated, particularly in patients with advanced
cancer, who often present with comorbid anxiety and depression for various reasons …

Poor access to mental healthcare is associated with worse postoperative outcomes among patients with gastrointestinal cancer

ES Katayama, S Woldesenbet, MM Munir… - Annals of Surgical …, 2024 - Springer
Background Mental health has an important role in the care of cancer patients, and access
to mental health services may be associated with improved outcomes. Thus, poor access to …

Level of selected exponents of the kynurenine pathway in patients diagnosed with depression and selected cancers

J Jasionowska, P Gałecki, E Kalinka, A Skiba… - Journal of Psychiatric …, 2024 - Elsevier
Altered immune system activity is one of the common pathomechanisms of depressive
disorders and cancer. The aim of this study is to evaluate level of selected elements of the …

[HTML][HTML] Synergistic effects of the combinational use of escitalopram oxalate and 5-fluorouracil on the inhibition of gastric cancer SNU-1 cells

VCH Chen, JY Huang, BS Tzang, TC Hsu… - International Journal of …, 2022 - mdpi.com
Owing to its high recurrence rate, gastric cancer (GC) is the leading cause of tumor-related
deaths worldwide. Besides surgical treatment, chemotherapy is the most commonly used …

Glioma induces atypical depression-like behaviors in mice through the 5-HT and glutamatergic synapse pathways

B Li, K Ran, Z Jing, W Han, X Peng - Biochemical and Biophysical …, 2024 - Elsevier
Glioma patients often undertake psychiatric disorders such as depression and anxiety.
There are several clinical epidemiological studies on glioma-associated depression, but …

A Ketogenic Diet Sensitizes Pancreatic Cancer to Inhibition of Glutamine Metabolism

O Hajihassani, M Zarei, A Roichman, A Loftus… - bioRxiv, 2024 - biorxiv.org
Pancreatic cancer is the third leading cause of cancer death in the United States, and while
conventional chemotherapy remains the standard treatment, responses are poor. Safe and …

Modulation of the Indolamine 2, 3 Dioxygenase Pathway as a Means of Treating Depression

N Ramos, T Ichim, E Lin, F Lin, RV Akana, S Kesari… - 2023 - osf.io
Despite significant progress made in understanding and treatment of Major Depressive
Disorder (MDD), conventional approaches still possess significant shortcomings, supporting …

Сравнительный анализ содержания триптофана и метаболитов кинуренинового и серотонинового путей у пациентов с артериальной гипертензией и …

МВ Кожевникова, АВ Кривова, ЕО Коробкова… - Кардиология, 2022 - lib.ossn.ru
Аннотация Цель Сравнительный анализ содержания триптофана (Трп) и его
метаболитов в сыворотке крови лиц без сердечно-сосудистых заболеваний (ССЗ) и …