Metabolism research is undergoing a renaissance because many diseases are increasingly
recognized as being characterized by perturbations in intracellular metabolic regulation …

Abstract The PI3K/AKT/mTOR and RAF/MEK/ERK pathways are commonly activated by
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …

Protein kinase B/Akt regulates cellular metabolism, survival, and proliferation in response to
hormones and growth factors. Hyperactivation of Akt is frequently observed in cancer, while …

PKC (protein kinase C) has been in the limelight since the discovery three decades ago that
it acts as a major receptor for the tumour-promoting phorbol esters. Phorbol esters, with their …

The protein kinase Akt is one of the primary effectors of growth factor signaling in the cell. Akt
responds specifically to the lipid second messengers phosphatidylinositol-3, 4, 5 …

The serine threonine protein kinase, Akt, is at the central hub of signaling pathways that
regulates cell growth, differentiation, and survival. The reciprocal relation that exists between …

The protein serine-threonine kinase Akt undergoes a substantial conformational change
upon activation, which is induced by the phosphorylation of two critical regulatory residues …

Linking cell signaling events to the fundamental physicochemical basis of the
conformational behavior of single molecules and ultimately to cellular function is a key …

Allostery is a fundamental and extensive mechanism of intramolecular signal transmission.
Allosteric drugs possess several unique pharmacological advantages over traditional …

The protein kinase Akt controls myriad signaling processes in cells, ranging from growth and
proliferation to differentiation and metabolism. Akt is activated by a combination of binding to …