Role of m6A writers, erasers and readers in cancer
Z Fang, W Mei, C Qu, J Lu, L Shang, F Cao… - … Hematology & Oncology, 2022 - Springer
Abstract The N (6)-methyladenosine (m6A) modification is the most pervasive modification of
human RNAs. In recent years, an increasing number of studies have suggested that m6A …
human RNAs. In recent years, an increasing number of studies have suggested that m6A …
FTO in cancer: functions, molecular mechanisms, and therapeutic implications
N 6-methyladenosine (m 6 A) is the most abundant internal modification in mRNA that
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …
[HTML][HTML] The m6A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function
L Ma, T Chen, X Zhang, Y Miao, X Tian, K Yu, X Xu… - Redox Biology, 2021 - Elsevier
The biological functions of N6-methyladenosine (m 6 A) RNA methylation are mainly
dependent on the reader; however, its role in lung tumorigenesis remains unclear. Here, we …
dependent on the reader; however, its role in lung tumorigenesis remains unclear. Here, we …
m6A modification in RNA: biogenesis, functions and roles in gliomas
Y Zhang, X Geng, Q Li, J Xu, Y Tan, M Xiao… - Journal of Experimental …, 2020 - Springer
The chemical modification of RNA is a newly discovered epigenetic regulation mechanism
in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) …
in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) …
The biological function of m6A demethylase ALKBH5 and its role in human disease
J Wang, J Wang, Q Gu, Y Ma, Y Yang, J Zhu… - Cancer cell …, 2020 - Springer
Abstract Human AlkB homolog H5 (ALKBH5) is a primary m6A demethylase, which is
dysregulated and acts as a biological and pharmacological role in human cancers or non …
dysregulated and acts as a biological and pharmacological role in human cancers or non …
RNA methylations in human cancers
RNA methylations, as the prevalent post-transcriptional modifications, are critical in
regulating various biological processes, such as RNA transcription, splicing, structure …
regulating various biological processes, such as RNA transcription, splicing, structure …
Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m6A modification
Y He, W Wang, X Xu, B Yang, X Yu, Y Wu, J Wang - Bone, 2022 - Elsevier
Abstract N 6-methyladenosine (m 6 A) methylation is one of the most common internal
modifications in eukaryotic messenger RNA occurring on N 6 nitrogen of adenosine …
modifications in eukaryotic messenger RNA occurring on N 6 nitrogen of adenosine …
RNA m6A modification in cancers: molecular mechanisms and potential clinical applications
N 6-Methyladenosine (m 6 A) RNA modification brings a new dawn for RNA modification
researches in recent years. This posttranscriptional RNA modification is dynamic and …
researches in recent years. This posttranscriptional RNA modification is dynamic and …
The emerging roles of RNA modifications in glioblastoma
Z Dong, H Cui - Cancers, 2020 - mdpi.com
Glioblastoma (GBM) is a grade IV glioma that is the most malignant brain tumor type.
Currently, there are no effective and sufficient therapeutic strategies for its treatment …
Currently, there are no effective and sufficient therapeutic strategies for its treatment …
Epigenetic activation of RBM15 promotes clear cell renal cell carcinoma growth, metastasis and macrophage infiltration by regulating the m6A modification of CXCL11
X Zeng, K Chen, L Li, J Tian, W Ruan, Z Hu… - Free Radical Biology …, 2022 - Elsevier
Clear cell renal cell carcinoma (ccRCC) is a common kidney malignancy that is
characterized by poor prognosis. RNA-binding motif protein 15 (RBM15) has been identified …
characterized by poor prognosis. RNA-binding motif protein 15 (RBM15) has been identified …