The HPV E6/E7 oncogenes: key factors for viral carcinogenesis and therapeutic targets

K Hoppe-Seyler, F Bossler, JA Braun, AL Herrmann… - Trends in …, 2018 - cell.com
Human papillomavirus (HPV)-induced cancers are expected to remain a major health
problem worldwide for decades. The growth of HPV-positive cancer cells depends on the …

[HTML][HTML] Opportunities and challenges for human papillomavirus vaccination in cancer

R Roden, PL Stern - Nature Reviews Cancer, 2018 - nature.com
The discovery of genotype 16 as the prototype oncogenic human papillomavirus (HPV)
initiated a quarter century of laboratory and epidemiological studies that demonstrated their …

Comprehensive control of human papillomavirus infections and related diseases

FX Bosch, TR Broker, D Forman, AB Moscicki… - Vaccine, 2013 - Elsevier
Infection with human papillomavirus (HPV) is recognized as one of the major causes of
infection-related cancer worldwide, as well as the causal factor in other diseases. Strong …

Trends and targets in antiviral phototherapy

A Wiehe, JM O'Brien, MO Senge - Photochemical & Photobiological …, 2019 - pubs.rsc.org
Photodynamic therapy (PDT) is a well-established treatment option in the treatment of
certain cancerous and pre-cancerous lesions. Though best-known for its application in …

Clinical implications of (epi) genetic changes in HPV-induced cervical precancerous lesions

RDM Steenbergen, PJF Snijders… - Nature Reviews …, 2014 - nature.com
Infection of cervical epithelium with high-risk human papilloma virus (hrHPV) might result in
productive or transforming cervical intraepithelial neoplasia (CIN) lesions, the morphology of …

Targeting persistent human papillomavirus infection

S Shanmugasundaram, J You - Viruses, 2017 - mdpi.com
While the majority of Human papillomavirus (HPV) infections are transient and cleared
within a couple of years following exposure, 10–20% of infections persist latently, leading to …

Molecular mechanisms underlying human papillomavirus E6 and E7 oncoprotein-induced cell transformation

S Mittal, L Banks - Mutation Research/Reviews in Mutation Research, 2017 - Elsevier
Human papillomaviruses (HPVs) are the causative agents of 5% of all human cancers, with
cervical cancer being the most important. Two viral oncoproteins, E6 and E7, are essential …

Immunologic treatments for precancerous lesions and uterine cervical cancer

P Vici, L Mariani, L Pizzuti, D Sergi, L Di Lauro… - Journal of Experimental …, 2014 - Springer
Abstract Development of HPV-associated cancers not only depends on efficient negative
regulation of cell cycle control that supports the accumulation of genetic damage, but also …

PI3K/AKT/mTOR signaling regulates the virus/host cell crosstalk in HPV-positive cervical cancer cells

F Bossler, K Hoppe-Seyler, F Hoppe-Seyler - International journal of …, 2019 - mdpi.com
Human papillomavirus (HPV)-induced cancers will remain a significant clinical challenge for
decades. Thus, the development of novel treatment strategies is urgently required, which …

Itch mechanisms and circuits

L Han, X Dong - Annual review of biophysics, 2014 - annualreviews.org
The itch-scratch reflex serves as a protective mechanism in everyday life. However, chronic
persistent itching can be devastating. Despite the clinical importance of the itch sensation, its …