Retinoic acid (RA) regulates many cellular behaviors during embryonic development and
adult homeostasis. Like other morphogens, RA forms gradients through the use of localized …

The inadequacy of existing therapeutic tools together with the paucity of organ donors have
always led medical researchers to innovate the current treatment methods or to discover …

Circadian clocks create a 24-hour temporal structure, which allows organisms to occupy a
niche formed by time rather than space. They are pervasive throughout nature, yet they …

Contrary to multicellular organisms that display segmentation during development,
communities of unicellular organisms are believed to be devoid of such sophisticated …

Genes encoding proteins in a common regulatory network are frequently located close to
one another on the chromosome to facilitate co-regulation or couple gene expression to …

Morphogens provide positional information for spatial patterns of gene expression during
development. However, stochastic effects such as local fluctuations in morphogen …

Starving Bacillus subtilis cells execute a gene expression program resulting in the formation
of stress-resistant spores. Sporulation master regulator, Spo0A, is activated by a …

Organisms have a remarkable capacity to respond to environmental change. They can
either respond directly, by means of phenotypic plasticity, or they can slowly adapt through …

Stochastic pulsing of gene expression can generate phenotypic diversity in a genetically
identical population of cells, but it is unclear whether it has a role in the development of …

Stem/progenitor cells have been widely evaluated as a promising therapeutic option for
heart failure (HF). Numerous clinical trials with stem/progenitor cell-based therapy (SCT) for …