Mitochondria are not only central organelles in metabolism and energy conversion but are
also platforms for cellular signaling cascades. Classically, the shape and ultrastructure of …

Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …

Mitochondrial dysfunction has been regarded as a hallmark of diabetic cardiomyopathy. In
addition to their canonical metabolic actions, mitochondria influence various other aspects of …

Mitochondria are highly dynamic organelles that constantly undergo fission and fusion.
Disruption of mitochondrial dynamics undermines their function and causes several human …

Mitochondrial function is vital for normal cellular processes. Mitochondrial damage and
oxidative stress have been greatly implicated in the progression of aging, along with the …

The steady-state morphology of the mitochondrial network is maintained by a balance of
constitutive fission and fusion reactions. Disruption of this steady-state morphology results in …

During cell division, it is critical to properly partition functional sets of organelles to each
daughter cell. The partitioning of mitochondria shares some common features with that of …

Permanent residency in the eukaryotic cell pressured the prokaryotic mitochondrial ancestor
to strategize for intracellular living. Mitochondria are able to autonomously integrate and …

Mitochondria are highly dynamic organelles that undergo frequent fusion and fission. Optic
atrophy 1 (OPA1) is an essential GTPase protein for both mitochondrial inner membrane …

Mitochondrial fission and fusion play critical roles in maintaining functional mitochondria
when cells experience metabolic or environmental stresses. Fusion helps mitigate stress by …