Mitochondria in health, disease, and aging

JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Mitochondrial dynamics and its involvement in disease

DC Chan - Annual review of pathology: mechanisms of disease, 2020 - annualreviews.org
The dynamic properties of mitochondria—including their fusion, fission, and degradation—
are critical for their optimal function in energy generation. The interplay of fusion and fission …

Pervasive functional translation of noncanonical human open reading frames

J Chen, AD Brunner, JZ Cogan, JK Nuñez, AP Fields… - Science, 2020 - science.org
Ribosome profiling has revealed pervasive but largely uncharacterized translation outside of
canonical coding sequences (CDSs). In this work, we exploit a systematic CRISPR-based …

Defective mitophagy in Alzheimer's disease

JA Pradeepkiran, PH Reddy - Ageing Research Reviews, 2020 - Elsevier
Alzheimer's disease (AD) is a progressive, mental illness without cure. Several years of
intense research on postmortem AD brains, cell and mouse models of AD have revealed …

Drp1-dependent mitochondrial fission in cardiovascular disease

J Jin, X Wei, X Zhi, X Wang, D Meng - Acta Pharmacologica Sinica, 2021 - nature.com
Mitochondria are highly dynamic organelles undergoing cycles of fusion and fission to
modulate their morphology, distribution, and function, which are referred as 'mitochondrial …

Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse

H Morton, S Kshirsagar, E Orlov, LE Bunquin… - Free Radical Biology …, 2021 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
memory loss and multiple cognitive impairments. AD is marked by multiple cellular changes …

Human Fis1 regulates mitochondrial dynamics through inhibition of the fusion machinery

R Yu, SB Jin, U Lendahl, M Nistér, J Zhao - The EMBO journal, 2019 - embopress.org
Mitochondrial dynamics is important for life. At center stage for mitochondrial dynamics, the
balance between mitochondrial fission and fusion is a set of dynamin‐related GTP ases that …

[HTML][HTML] The Drp1-mediated mitochondrial fission protein interactome as an emerging core player in mitochondrial dynamics and cardiovascular disease therapy

M Zerihun, S Sukumaran, N Qvit - International Journal of Molecular …, 2023 - mdpi.com
Mitochondria, the membrane-bound cell organelles that supply most of the energy needed
for cell function, are highly regulated, dynamic organelles bearing the ability to alter both …

[HTML][HTML] Regulation of mammalian mitochondrial dynamics: opportunities and challenges

R Yu, U Lendahl, M Nistér, J Zhao - Frontiers in endocrinology, 2020 - frontiersin.org
Mitochondria are highly dynamic organelles and important for a variety of cellular functions.
They constantly undergo fission and fusion events, referred to as mitochondrial dynamics …

[HTML][HTML] MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size

TL Lewis Jr, SK Kwon, A Lee, R Shaw… - Nature …, 2018 - nature.com
Neurons display extreme degrees of polarization, including compartment-specific organelle
morphology. In cortical, long-range projecting, pyramidal neurons (PNs), dendritic …