Mitochondria in health, disease, and aging
JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …
Mitochondrial dynamics and its involvement in disease
DC Chan - Annual review of pathology: mechanisms of disease, 2020 - annualreviews.org
The dynamic properties of mitochondria—including their fusion, fission, and degradation—
are critical for their optimal function in energy generation. The interplay of fusion and fission …
are critical for their optimal function in energy generation. The interplay of fusion and fission …
Pervasive functional translation of noncanonical human open reading frames
Ribosome profiling has revealed pervasive but largely uncharacterized translation outside of
canonical coding sequences (CDSs). In this work, we exploit a systematic CRISPR-based …
canonical coding sequences (CDSs). In this work, we exploit a systematic CRISPR-based …
Defective mitophagy in Alzheimer's disease
JA Pradeepkiran, PH Reddy - Ageing Research Reviews, 2020 - Elsevier
Alzheimer's disease (AD) is a progressive, mental illness without cure. Several years of
intense research on postmortem AD brains, cell and mouse models of AD have revealed …
intense research on postmortem AD brains, cell and mouse models of AD have revealed …
Drp1-dependent mitochondrial fission in cardiovascular disease
J Jin, X Wei, X Zhi, X Wang, D Meng - Acta Pharmacologica Sinica, 2021 - nature.com
Mitochondria are highly dynamic organelles undergoing cycles of fusion and fission to
modulate their morphology, distribution, and function, which are referred as 'mitochondrial …
modulate their morphology, distribution, and function, which are referred as 'mitochondrial …
Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse
H Morton, S Kshirsagar, E Orlov, LE Bunquin… - Free Radical Biology …, 2021 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
memory loss and multiple cognitive impairments. AD is marked by multiple cellular changes …
memory loss and multiple cognitive impairments. AD is marked by multiple cellular changes …
Human Fis1 regulates mitochondrial dynamics through inhibition of the fusion machinery
Mitochondrial dynamics is important for life. At center stage for mitochondrial dynamics, the
balance between mitochondrial fission and fusion is a set of dynamin‐related GTP ases that …
balance between mitochondrial fission and fusion is a set of dynamin‐related GTP ases that …
[HTML][HTML] The Drp1-mediated mitochondrial fission protein interactome as an emerging core player in mitochondrial dynamics and cardiovascular disease therapy
Mitochondria, the membrane-bound cell organelles that supply most of the energy needed
for cell function, are highly regulated, dynamic organelles bearing the ability to alter both …
for cell function, are highly regulated, dynamic organelles bearing the ability to alter both …
[HTML][HTML] Regulation of mammalian mitochondrial dynamics: opportunities and challenges
Mitochondria are highly dynamic organelles and important for a variety of cellular functions.
They constantly undergo fission and fusion events, referred to as mitochondrial dynamics …
They constantly undergo fission and fusion events, referred to as mitochondrial dynamics …
[HTML][HTML] MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size
Neurons display extreme degrees of polarization, including compartment-specific organelle
morphology. In cortical, long-range projecting, pyramidal neurons (PNs), dendritic …
morphology. In cortical, long-range projecting, pyramidal neurons (PNs), dendritic …