Microneedles are a rapidly developing method for the transdermal delivery of therapeutic
compounds. All types of microneedles, whether solid, hollow, coated, or dissolving function …

Cationic antimicrobial peptides (AMPs) are an intrinsic part of the human innate immune
system. Over 100 different human AMPs are known to exhibit broad-spectrum antibacterial …

The microbiome can promote or disrupt human health by influencing both adaptive and
innate immune functions. We tested whether bacteria that normally reside on human skin …

The human cathelicidin hCAP18/LL-37 has become a paradigm for the pleiotropic roles of
peptides in host defence. It has a remarkably wide functional repertoire that includes direct …

We report the discovery that strains of Staphylococcus epidermidis produce 6-N-
hydroxyaminopurine (6-HAP), a molecule that inhibits DNA polymerase activity. In culture, 6 …

Cathelicidins are short cationic peptides that are part of the innate immune system. At first,
these peptides were studied mostly for their direct antimicrobial killing capacity, but …

This review examines the role of reactive species RS (of oxygen ROS, nitrogen RNS and
halogen RHS) on innate immunity. The importance of these species in innate immunity was …

Antimicrobial peptides (AMPs) are widely expressed and rapidly induced at epithelial
surfaces to repel assault from diverse infectious agents including bacteria, viruses, fungi and …

Almost 90 years have passed since Alexander Fleming discovered the antimicrobial activity
of lysozyme, the first natural antibiotic isolated from our body. Since then, various types of …

Antimicrobial peptides and their precursor molecules form a central part of human and
mammalian innate immunity. The underlying genes have been thoroughly investigated and …