Background: Acetylcholinesterase is a serine hydrolase that terminates the action of the
neurotransmitter acetylcholine by hydrolyzing it into acetic acid and choline. Objective: The …

Acetylcholinesterase and butyrylcholinesterase are the two enzymes involved in the
cholinergic system and its modulation. These enzymes have been recognized as …

In this research, we have implemented two-dimensional quantitative structure-activity
relationship (2D-QSAR) modeling using two different datasets, namely, acetylcholinesterase …

Coumarins have been widely used in various human systemic diseases; however, their
molecular action is not known in many cases. In silico studies are an option to explore the …

Synthesis of a compound with balanced bioactivities against a specific target is always a
challenging task. In this study, a novel compound (1) has been synthesized by combination …

Phormidium autumnale (P. autumnale) is a cyanobacteria with an unknown metabolic
system, since only few studies have been reported. Among the produced metabolites …

Given the wide spectrum of biological uses of pyrazolo [1, 5-c] quinazoline and spiro-
quinazoline derivatives as anticancer, anti-inflammatory analgesic agents, and their …

Alzheimer's disease is a chronic neurodegenerative disease, which is characterized mainly
by a progressive decrease in intellectual abilities, memory impairment and a change in a …

Despite the constant progress in the understanding of the etiopathogenesis of Alzheimer's
disease (AD) over the last 50 years, just four long-standing drugs are currently used for AD …

Rivastigmine is a very important drug prescribed for the treatment of Alzheimer's disease
(AD) symptoms. It is a dual inhibitor, in that it inhibits both acetylcholinesterase (AChE) and …