Progress in renal transplantation requires improved understanding and assessment of
rejection and injury. Study of the relationship between gene expression and clinical …

Graft inflammation impairs the induction of solid organ transplant tolerance and enhances
acute and chronic rejection. Elucidating the mechanisms by which inflammation is induced …

Using meta-analysis of eight independent transplant datasets (236 graft biopsy samples)
from four organs, we identified a common rejection module (CRM) consisting of 11 genes …

Background Chronic injury in kidney transplants remains a major cause of allograft loss. The
aim of this study was to identify a gene set capable of predicting renal allografts at risk of …

In chronic kidney disease (CKD), progressive nephron loss causes glomerular sclerosis, as
well as tubulointerstitial fibrosis and progressive tubular injury. In this study, we aimed to …

Background Development of noninvasive molecular assays to improve disease diagnosis
and patient monitoring is a critical need. In renal transplantation, acute rejection (AR) …

Inflammation within areas of interstitial fibrosis and tubular atrophy (i-IFTA) is associated with
adverse outcomes in kidney transplantation. We evaluated i-IFTA in 429 indication-and …

Background The relative impact on renal allograft outcome of specific histological diagnoses
versus nonspecific chronic histological damage remains unclear. Methods All 1,197 renal …

Accurate and noninvasive monitoring of renal allograft posttransplant is essential for early
detection of acute rejection (AR) and to affect the long-term survival of the transplant. We …

Genomics, proteomics and molecular biology lead to tremendous advances in all fields of
medical sciences. Among these the finding of biomarkers as non invasive indicators of …