The family of VPS10p-Domain (D) receptors comprises five members named SorLA, Sortilin,
SorCS1, SorCS2 and SorCS3. While their physiological roles remain incompletely resolved …

Recent studies have found abnormal levels of brain-derived neurotrophic factor (BDNF) in a
variety of central nervous system (CNS) diseases (eg, stroke, depression, anxiety …

Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in
2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild …

In Alzheimer's disease (AD), a single-nucleotide polymorphism in the gene encoding brain-
derived neurotrophic factor (BDNF Val66Met) is associated with worse impact of primary AD …

Neurotrophins are a well-known family of neurotrophic factors that play an important role
both in the central and peripheral nervous systems, where they modulate neuronal survival …

Objective Previous studies suggest that the brain‐derived neurotrophic factor (BDNF)
Val66Met (rs6265) polymorphism may influence symptom onset in Alzheimer's disease …

Health promotion and healthy nutrition significantly increased life expectancy around the
world. Aging is associated with an increase in age‐related diseases. The use of metformin …

Background: There is a paucity of information on the role of microvascular and inflammatory
biomarkers in cognitive dysfunction. Objective: This study sought to evaluate the …

Methods: Bacopa was administered in an open-labeled study to cognitively healthy controls
over a 3-month period. Cognition and mood were assessed using the Montreal Cognitive …

Vascular dementia, caused by cerebrovascular disease, is associated with cognitive
impairment and reduced hippocampal metabolite levels. Specifically, cognitive impairment …