Introducing novel strategies, concepts, and technologies that speed up drug discovery and
the drug development cycle is of great importance both in the highly competitive …

Introduction: Under normal conditions, hepatocyte growth factor (HGF)-induced activation of
its cell surface receptor, the Met tyrosine kinase (TK), is tightly regulated by paracrine ligand …

Computer-aided drug design plays a vital role in drug discovery and development and has
become an indispensable tool in the pharmaceutical industry. Computational medicinal …

Virtual screening has played a significant role in the discovery of small molecule inhibitors of
therapeutic targets in last two decades. Various ligand and structure-based virtual screening …

Protein kinase inhibitors are a well-established class of clinically useful drugs, particularly
for the treatment of cancer. Achieving inhibitor selectivity for particular protein kinases often …

The proto-oncogene receptor tyrosine kinase c-Met encodes the high-affinity receptor for
hepatocyte growth factor (HGF). Dysregulation of the HGF‐c-Met pathway plays a significant …

The functional characterization of proteins represents a daily challenge for biochemical,
medical and computational sciences. Although finally proved on the bench, the function of a …

By use of an improved synthetic strategy, a series of 3, 5-disubstituted and 3, 5, 7-
trisubstituted quinolines were readily prepared. 3, 5, 7-Trisubstituted quinolines 21a− c, 21l …

Targeting somatically activated oncogenes has revolutionized the treatment of non–small
cell lung cancer (NSCLC). Mutations in the gene mesenchymal–epithelial transition (MET) …

Abstract A series of 6, 7-disubstituted-4-(2-fluorophenoxy) quinoline derivatives possessing
1, 2, 3-triazole-4-carboxamide moiety were designed, synthesized and evaluated for their in …