Genetics of rheumatoid arthritis
L Padyukov - Seminars in immunopathology, 2022 - Springer
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease involving symmetric joints
and is generally characterized by persistent pain, tenderness, and destruction of joints. The …
and is generally characterized by persistent pain, tenderness, and destruction of joints. The …
Molecular and cellular heterogeneity in rheumatoid arthritis: mechanisms and clinical implications
Rheumatoid arthritis is an autoimmune disease that exhibits significant clinical
heterogeneity. There are various treatments for rheumatoid arthritis, including disease …
heterogeneity. There are various treatments for rheumatoid arthritis, including disease …
Single-cell eQTL mapping identifies cell type–specific genetic control of autoimmune disease
The human immune system displays substantial variation between individuals, leading to
differences in susceptibility to autoimmune disease. We present single-cell RNA sequencing …
differences in susceptibility to autoimmune disease. We present single-cell RNA sequencing …
Vitamin D, autoimmune disease and rheumatoid arthritis
SR Harrison, D Li, LE Jeffery, K Raza… - Calcified tissue …, 2020 - Springer
Vitamin D has been reported to influence physiological systems that extend far beyond its
established functions in calcium and bone homeostasis. Prominent amongst these are the …
established functions in calcium and bone homeostasis. Prominent amongst these are the …
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus
DL Morris, Y Sheng, Y Zhang, YF Wang, Z Zhu… - Nature …, 2016 - nature.com
Systemic lupus erythematosus (SLE; OMIM 152700) is a genetically complex autoimmune
disease. Genome-wide association studies (GWASs) have identified more than 50 loci as …
disease. Genome-wide association studies (GWASs) have identified more than 50 loci as …
Functions and regulation of T cell-derived interleukin-10
Abstract Interleukin (IL)-10 is an essential anti-inflammatory cytokine and functions as a
negative regulator of immune responses to microbial antigens. IL-10 is particularly important …
negative regulator of immune responses to microbial antigens. IL-10 is particularly important …
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis
S Bell, AS Rigas, MK Magnusson… - Communications …, 2021 - nature.com
Iron is essential for many biological functions and iron deficiency and overload have major
health implications. We performed a meta-analysis of three genome-wide association …
health implications. We performed a meta-analysis of three genome-wide association …
Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus
Systemic lupus erythematosus is a heritable autoimmune disease that predominantly affects
young women. To improve our understanding of genetic etiology, we conduct multi-ancestry …
young women. To improve our understanding of genetic etiology, we conduct multi-ancestry …
An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes
There is a need for better classification and understanding of tumor-infiltrating lymphocytes
(TILs). Here, we applied advanced functional genomics to interrogate 9,000 human tumors …
(TILs). Here, we applied advanced functional genomics to interrogate 9,000 human tumors …
OX40 ligand contributes to human lupus pathogenesis by promoting T follicular helper response
C Jacquemin, N Schmitt, C Contin-Bordes, Y Liu… - Immunity, 2015 - cell.com
Increased activity of T follicular helper (Tfh) cells plays a major pathogenic role in systemic
lupus erythematosus (SLE). However, the mechanisms that cause aberrant Tfh cell …
lupus erythematosus (SLE). However, the mechanisms that cause aberrant Tfh cell …