The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives

S Wang, Y Zheng, F Yang, L Zhu, XQ Zhu… - Signal transduction and …, 2021 - nature.com
Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …

Small nucleolar RNAs: insight into their function in cancer

J Liang, J Wen, Z Huang, X Chen, B Zhang… - Frontiers in …, 2019 - frontiersin.org
Small nucleolar RNAs (SnoRNAs) are a class of non-coding RNAs divided into two classes:
C/D box snoRNAs and H/ACA box snoRNAs. The canonical function of C/D box and H/ACA …

Decoding pseudouridine: an emerging target for therapeutic development

J Cerneckis, Q Cui, C He, C Yi, Y Shi - Trends in pharmacological sciences, 2022 - cell.com
Pseudouridine (Ψ) is the most abundant post-transcriptional RNA modification and is
widespread in multiple RNA species. Ψ impacts various aspects of RNA biology, conferring …

A pan-cancer analysis of the expression and clinical relevance of small nucleolar RNAs in human cancer

J Gong, Y Li, C Liu, YU Xiang, C Li, Y Ye, Z Zhang… - Cell reports, 2017 - cell.com
Increasing evidence has demonstrated that small nucleolar RNAs (snoRNAs) play important
roles in tumorigenesis. We systematically investigated the expression landscape and clinical …

Non-coding RNAs and epithelial mesenchymal transition in cancer: molecular mechanisms and clinical implications

H Khanbabaei, S Ebrahimi… - Journal of Experimental …, 2022 - Springer
Epithelial-mesenchymal transition (EMT) is a fundamental process for embryonic
development during which epithelial cells acquire mesenchymal characteristics, and the …

Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer

Y Zheng, C Wu, J Yang, Y Zhao, H Jia, M Xue… - Signal transduction and …, 2020 - nature.com
Abstract Enolase 2 (ENO2) is a key glycolytic enzyme in the metabolic process of glycolysis,
but its potential function in pancreatic ductal adenocarcinoma (PDAC) is unclear. In this …

Non-coding small nucleolar RNA SNORD17 promotes the progression of hepatocellular carcinoma through a positive feedback loop upon p53 inactivation

J Liang, G Li, J Liao, Z Huang, J Wen, Y Wang… - Cell Death & …, 2022 - nature.com
Recent evidence suggests that small nucleolar RNAs (snoRNAs) are involved in the
progression of various cancers, but their precise roles in hepatocellular carcinoma (HCC) …

Small extracellular vesicle non-coding RNAs in pancreatic cancer: molecular mechanisms and clinical implications

M Reese, SA Dhayat - Journal of hematology & oncology, 2021 - Springer
Pancreatic cancer has the worst prognosis among common tumors which is attributed to its
aggressive phenotype, diagnosis at advanced, inoperable stages, and resistance to …

p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis

T Anwar, C Arellano-Garcia, J Ropa, YC Chen… - Nature …, 2018 - nature.com
Overexpression of EZH2 in estrogen receptor negative (ER-) breast cancer promotes
metastasis. EZH2 has been mainly studied as the catalytic component of the Polycomb …

SnoRNA in cancer progression, metastasis and immunotherapy response

J van der Werf, CV Chin, NI Fleming - Biology, 2021 - mdpi.com
Simple Summary A much larger number of small nucleolar RNA (snoRNA) have been found
encoded within our genomes than we ever expected to see. The activities of the snoRNAs …