Effect of micro-and nanoparticle shape on biological processes

H Hadji, K Bouchemal - Journal of Controlled Release, 2022 - Elsevier
In the drug delivery field, there is beyond doubt that the shape of micro-and nanoparticles
(M&NPs) critically affects their biological fate. Herein, following an introduction describing …

Materials for blood brain barrier modeling in vitro

MP Ferro, SC Heilshorn, RM Owens - Materials Science and Engineering …, 2020 - Elsevier
Brain homeostasis relies on the selective permeability property of the blood brain barrier
(BBB). The BBB is formed by a continuous endothelium that regulates exchange between …

[HTML][HTML] Cell orientation under stretch: A review of experimental findings and mathematical modelling

C Giverso, N Loy, G Lucci, L Preziosi - Journal of Theoretical Biology, 2023 - Elsevier
The key role of electro-chemical signals in cellular processes had been known for many
years, but more recently the interplay with mechanics has been put in evidence and …

The effect of cyclic stretch on aortic viscoelasticity and the putative role of smooth muscle focal adhesion

CHG Neutel, CD Wesley, GRY De Meyer… - Frontiers in …, 2023 - frontiersin.org
Due to its viscoelastic properties, the aorta aids in dampening blood pressure pulsatility. At
the level of resistance-arteries, the pulsatile flow will be transformed into a continuous flow to …

High Pulsatile Load Decreases Arterial Stiffness: An ex vivo Study

CHG Neutel, G Corradin, P Puylaert… - Frontiers in …, 2021 - frontiersin.org
Measuring arterial stiffness has recently gained a lot of interest because it is a strong
predictor for cardiovascular events and all-cause mortality. However, assessing blood …

Studies of osteoblast-like MG-63 cellular proliferation and differentiation with cyclic stretching cell culture system on biomimetic hydrophilic layers modified …

SJ Tseng, CH Cheng, TM Lee, JC Lin - Biochemical Engineering Journal, 2021 - Elsevier
Cell culturing with physical stimulation has been in research focus lately because the human
body and tissue are continuously receiving different mechanical stress in daily activities …

Efficient flocking: metric versus topological interactions

V Kumar, R De - Royal Society open science, 2021 - royalsocietypublishing.org
Flocking is a fascinating phenomenon observed across a wide range of living organisms.
We investigate, based on a simple self-propelled particle model, how the emergence of …

Zyxin and actin structure confer anisotropic YAP mechanotransduction

SM Wen, WC Wen, PG Chao - Acta Biomaterialia, 2022 - Elsevier
Tissues and the embedded cells experience anisotropic deformations due to their functions
and anatomical locations. The resident cells, such as tenocytes and muscle cells, are often …

[HTML][HTML] Sonomechanobiology: Vibrational stimulation of cells and its therapeutic implications

LA Ambattu, LY Yeo - Biophysics Reviews, 2023 - pubs.aip.org
All cells possess an innate ability to respond to a range of mechanical stimuli through their
complex internal machinery. This comprises various mechanosensory elements that detect …

Pulmonary endothelial mechanical sensing and signaling, a story of focal adhesions and integrins in ventilator induced lung injury

GT Kelly, R Faraj, Y Zhang, E Maltepe… - Frontiers in …, 2019 - frontiersin.org
Patients with critical illness such as acute lung injury often undergo mechanical ventilation in
the intensive care unit. Though lifesaving in many instances, mechanical ventilation often …