Perfluoropyridine: discovery, chemistry, and applications in polymers and material science

R Gautam, I Geniza, ST Iacono, CM Friesen… - Molecules, 2022 - mdpi.com
Perfluoropyridine (PFPy) is an organofluorine compound that has been employed for a
variety of applications, from straightforward chemical synthesis to more advanced functions …

[HTML][HTML] Synthesis of complex unnatural fluorine-containing amino acids

WDG Brittain, CM Lloyd, SL Cobb - Journal of Fluorine Chemistry, 2020 - Elsevier
The area of fluorinated amino acid synthesis has seen rapid growth over the past decade.
As reports of singly fluorinated natural amino acid derivatives have grown, researchers have …

Quantification of Phenolic Hydroxyl Groups in Lignin via 19F NMR Spectroscopy

JK Kenny, JW Medlin, GT Beckham - ACS Sustainable Chemistry …, 2023 - ACS Publications
Phenolic moieties strongly influence lignin reactivity and physical properties, and thus
accurate quantification of phenolic groups in lignin is a critical analytical chemistry need …

Carboxylic acid deoxyfluorination and one-pot amide bond formation using pentafluoropyridine (PFP)

WDG Brittain, SL Cobb - Organic Letters, 2021 - ACS Publications
This work describes the application of pentafluoropyridine (PFP), a cheap commercially
available reagent, in the deoxyfluorination of carboxylic acids to acyl fluorides. The acyl …

One-pot ester and thioester formation mediated by pentafluoropyridine (PFP)

LND Beardmore, SL Cobb, WDG Brittain - Organic & Biomolecular …, 2022 - pubs.rsc.org
Acyl fluorides are valuable synthetic intermediates, but in some cases they can be
challenging to handle and difficult to isolate given their susceptibility to degradation. In …

Total synthesis of the natural chalcone lophirone E, synthetic studies toward benzofuran and indole-based analogues, and investigation of anti-leishmanial activity

L Pozzetti, R Ibba, S Rossi, O Taglialatela-Scafati… - Molecules, 2022 - mdpi.com
The potential of natural and synthetic chalcones as therapeutic leads against different
pathological conditions has been investigated for several years, and this class of …

Au (I) Catalyzed HF Transfer: Tandem Alkyne Hydrofluorination and Perfluoroarene Functionalization

D Mulryan, J Rodwell, NA Phillips, MR Crimmin - ACS catalysis, 2022 - ACS Publications
HF transfer reactions between organic substrates are potentially useful transformations.
Such reactions require the development of catalytic systems that can promote both …

Perfluoroaryl and perfluoroheteroaryl reagents as emerging new tools for peptide synthesis, modification and bioconjugation

WDG Brittain, CR Coxon - Chemistry–A European Journal, 2022 - Wiley Online Library
Peptides and proteins are becoming increasingly valuable as medicines, diagnostic agents
and as tools for biomedical sciences. Much of this has been underpinned by the emergence …

Shaken not stirred: perfluoropyridine-polyalkylether prepolymers

CM Friesen, AR Kelley, ST Iacono - Macromolecules, 2022 - ACS Publications
The purpose of this work was to employ perfluoropolyalkylethers (PFPAEs) with
perfluoropyridines (PFPs) to form telechelic oligomers for use in low-temperature materials …

Pentafluorobenzene: Promising Applications in Diagnostics and Therapeutics

RR Nair, EW Seo, S Hong, KO Jung… - ACS Applied Bio …, 2023 - ACS Publications
Pentafluorobenzene (PFB) represents a class of aromatic fluorine compounds employed
exclusively across a spectrum of chemical and biological applications. PFBs are credited …