Regulation of nonribosomal peptide synthesis: bis-thiomethylation attenuates gliotoxin biosynthesis in Aspergillus fumigatus

SK Dolan, RA Owens, G O'Keeffe, S Hammel… - Chemistry & biology, 2014 - cell.com
Gliotoxin is a redox-active nonribosomal peptide produced by Aspergillus fumigatus. Like
many other disulfide-containing epipolythiodioxopiperazines, a bis-thiomethylated form is …

Effects of environmental stress factors on the actin cytoskeleton of fungi and plants: Ionizing radiation and ROS

OOH Stephan - Cytoskeleton, 2023 - Wiley Online Library
Actin is an abundant and multifaceted protein in eukaryotic cells that has been detected in
the cytoplasm as well as in the nucleus. In cooperation with numerous interacting accessory …

Genomic and functional insights into the diversification of the elongation factor eEF1Bγ in fungi

J Renou, R Sormani, E Gelhaye, C Didierjean… - Fungal Biology …, 2022 - Elsevier
Abstract eEF1Bγs are proteins found in all eukaryotes and have a role in protein translation,
being part of the nucleotide exchange factor eEF1B of the elongation factor complex 1. They …

Interplay between gliotoxin resistance, secretion, and the methyl/methionine cycle in Aspergillus fumigatus

RA Owens, G O'Keeffe, EB Smith, SK Dolan… - Eukaryotic …, 2015 - Am Soc Microbiol
Mechanistic studies on gliotoxin biosynthesis and self-protection in Aspergillus fumigatus,
both of which require the gliotoxin oxidoreductase GliT, have revealed a rich landscape of …

Impact of the antifungal protein PgAFP from Penicillium chrysogenum on the protein profile in Aspergillus flavus

J Delgado, RA Owens, S Doyle, MA Asensio… - Applied microbiology …, 2015 - Springer
Antifungal proteins produced by molds are generally small, highly basic, and cysteine-rich.
The best known effects of these proteins include morphological changes, metabolic …

A Proteomic Approach to Investigating Gene Cluster Expression and Secondary Metabolite Functionality in Aspergillus fumigatus

RA Owens, S Hammel, KJ Sheridan, GW Jones… - PloS one, 2014 - journals.plos.org
A combined proteomics and metabolomics approach was utilised to advance the
identification and characterisation of secondary metabolites in Aspergillus fumigatus. Here …

Non-translational Connections of eEF1B in the Cytoplasm and Nucleus of Cancer Cells

B Negrutskii - Frontiers in Molecular Biosciences, 2020 - frontiersin.org
The human translation machinery includes three types of supramolecular complexes
involved in elongation of the polypeptide chain: the ribosome, complex of elongation factors …

Increased chitin biosynthesis contributes to the resistance of Penicillium polonicum against the antifungal protein PgAFP

J Delgado, RA Owens, S Doyle, MA Asensio… - Applied microbiology …, 2016 - Springer
Antifungal proteins from molds have been proposed as a valuable tool against unwanted
molds, but the resistance of some fungi limits their use. Resistance to antimicrobial peptides …

Proteomic analysis of Aspergillus fumigatus – clinical implications

NM Moloney, RA Owens, S Doyle - Expert Review of Proteomics, 2016 - Taylor & Francis
Introduction: Aspergillus fumigatus is a ubiquitous saprophytic fungus capable of producing
small airborne spores, which are frequently inhaled by humans. In healthy individuals, the …

Mass-spectrometric and bioinformatic analysis of eEF1Bγ interactome in the cytoplasmic fraction of A549 cells

LM Kapustian, IL Lysetsky, TV Bondarchuk… - Вiopolymers and …, 2018 - dspace.nbuv.gov.ua
Aim. To study protein networks containing the translation elongation factor eEF1B gamma
(eEF1Bγ) in lung carcinoma cells. Methods. The protein partners of eEF1Bγ in the …