Steroid Receptor Coactivators (SRCs) are essential regulators of transcription with a wide
range of impact on human physiology and pathology. In immunology, SRCs play multiple …

Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is
a member of the SRC family. SRC-3 regulates not only the transcriptional activity of nuclear …

High aerobic glycolysis not only provides energy to cancer cells, but also supports their
anabolic growth. JMJD1A, a histone demethylase that specifically demethylates …

Chemoresistance is a major obstacle to effective breast cancer chemotherapy. However, the
underlying molecular mechanisms remain unclear. In this study, nuclear receptor coactivator …

The histone demethylase Jumonji domain containing 1A (JMJD1A) is overexpressed in
multiple tumors and promotes cancer progression. JMJD1A has been shown to promote …

Overexpression of nuclear coactivator steroid receptor coactivator 1 (SRC-1) and aberrant
activation of the Hedgehog (Hh) signaling pathway are associated with various …

Coactivators represent a large class of proteins that partner with nuclear receptors and other
transcription factors to regulate gene expression. Given their pleiotropic roles in the control …

Cancer invasion and metastasis accounts for the majority of cancer related mortality. A better
understanding of the players that drive the aberrant invasion and migration of tumors cells …

Nuclear receptor coactivator 3 (NCOA 3) is a transcriptional coactivator that has elevated
expression in multiple tumor types, including colorectal cancer (CRC). However, the …

Background Protein arginine methylation reaction is catalyzed by protein arginine
methyltransferase (PRMT) and the modification is implicated in various diseases including …