Delivery of exogenous mRNA using lipid nanoparticles (LNPs) is a promising strategy for
therapeutics. However, a bottleneck remains in the poor understanding of the parameters …

Elucidating protein functions and molecular organisation requires to localise precisely single
or aggregated molecules and analyse their spatial distributions. We develop a statistical …

An outstanding question is how receptor tyrosine kinases (RTKs) determine different cell-
fate decisions despite sharing the same signalling cascades. Here, we uncovered an …

Mitochondrial stress response is essential for cell survival, and damaged mitochondria are a
hallmark of neurodegenerative diseases. Thus, it is fundamental to understand how …

Endocytosis allows cargo to enter a series of specialized endosomal compartments,
beginning with early endosomes harboring Rab5 and its effector EEA1. There are, however …

Abstract The Blood-Brain Barrier (BBB) restricts access of large molecules to the brain. The
low endocytic activity of brain endothelial cells (BECs) is believed to limit delivery of …

Platelet-derived growth factor receptor β (PDGFRβ) is a receptor tyrosine kinase which upon
activation by PDGF-BB stimulates cell proliferation, migration and angiogenesis. Ligand …

Background Lymphotoxin β receptor (LTβR) plays important roles in the development of the
immune system and immune response. At the cellular level, ligand-bound LTβR activates …

Local translation is vital to polarized cells such as neurons and requires a precise and
robust distribution of different mRNAs and the translation machinery across the entire cell …

Localized translation is vital to polarized cells and requires precise and robust distribution of
different mRNAs and ribosomes across the cell. However, the underlying molecular …