Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …

One common and reversible type of post-translational modification (PTM) is the addition of O-
linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation), and its dynamic …

Background O-linked β-N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) is a
key enzyme that regulates O-GlcNAc modification, which is significantly up-regulated and …

Cognitive impairment caused by systemic chemotherapy is a critical question that perplexes
the effective implementation of clinical treatment, but related molecular events are poorly …

Inflammatory response triggered by nerve injury plays important roles in the development of
neurological disorders, such as neuropathic pain. The signaling events leading to …

Remifentanil is a widely used in general anesthetic that has been found to suppress the
inflammatory response in aortic endothelial cells. Therefore, it was hypothesized that …

The ubiquitin–proteasome system (UPS) is responsible for proteasomal degradation,
regulating the half-life of the protein. Deubiquitinating enzymes (DUBs) are components of …

Introduction: Fat mass and obesity-associated (FTO) gene is strongly associated with obesity
which brings a major health threat. Altered expression of its encoded protein FTO in the …

One of the changes brought about by Wallerian degeneration distal to nerve injury is
disintegration of axonal mitochondria and consequent leakage of mitochondrial DNA …

Activated Schwann cells put out cytoplasmic processes that play a significant role in cell
migration and axon regeneration. Following nerve injury, axonal mitochondria release …