Sickle cell disease is an autosomal recessive disorder of the beta-globin gene, with resultant
deformation of the red blood cells and variable clinical outcomes. Nigeria is recognised as …

Background Foetal haemoglobin (HbF) is a major modifying factor influencing sickle cell
disease (SCD) severity. Despite this, HbF estimation is not routinely done in Nigeria. The …

Sickle cell anemia (SCA) is an autosomal recessive monogenic disease with significant
clinical variability. Cerebrovascular disease, particularly ischemic stroke, is one of the most …

Methods Red cell indices, blood film, sickle solubility test, Hb electrophoresis using alkaline
cellulose acetate membrane, and chromatographic patterns using Bio Rad HPLC Variant II …

Background: Sickle cell anemia (SCA) is a major global public health concern. Fetal
hemoglobin level (HbF) is a major modulating factor of the clinical manifestation of the …

Objectives: This study aimed to determine the malaria parasite density in children with
homozygous sickle cell disease and compare it with the splenic size and fetal Hb (HbF) …

Background: Foetal haemoglobin (HbF, α2γ2) retards polymerisation of haemoglobin (Hb) in
sickle cell anaemia (SCA). In Nigeria, studies on the levels of HbF and its relationship with …

Sickle cell disease (SCD) remains a significant global health challenge, particularly affecting
populations in regions with limited healthcare resources. In response to this pressing need …

Sickle cell anemia (SCA) is a chronic hemolytic disorder. It is considered as a major health
problem in Syria. The risk of this disease varies among patients worldwide. Fetal …

Sickle cell disease (SCD) presents unique challenges for adolescents, impacting their
physical health, psychosocial well-being, and quality of life. In recent years, social media …