The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a
formidable treatment challenge across neuropsychiatric disorders. In major depressive …

Computational psychiatry is a rapidly growing field attempting to translate advances in
computational neuroscience and machine learning into improved outcomes for patients …

Anhedonia is one of the core symptoms of major depressive disorder (MDD), which is often
inadequately treated by traditional antidepressants. The modern framework of anhedonia …

The inability to experience pleasure or interest in activities (commonly referred to in clinical
settings as anhedonia) is characteristic of depression, anxiety, post-traumatic stress disorder …

Effective psychotherapies for late-life depression are underutilized, mainly because of their
complexity.“Engage” is a novel, streamlined psychotherapy that relies on neurobiology to …

In order to develop effective treatments for anhedonia we need to understand its underlying
neurobiological mechanisms. Anhedonia is conceptually strongly linked to reward …

Despite the prominence of anhedonic symptoms associated with diverse neuropsychiatric
conditions, there are currently no approved therapeutics designed to attenuate the loss of …

Neuropathic pain is a chronic debilitating condition with a high comorbidity with depression.
Clinical reports and animal studies have suggested that both the medial prefrontal cortex …

Anhedonia is a reduction in enjoyment, motivation, or interest. It is common across mental
health disorders and a harbinger of poor treatment outcomes. The enjoyment aspect, termed …