Significance: Recent clinical evidence identified anemia to be correlated with severe
complications of cardiovascular disease (CVD) such as bleeding, thromboembolic events …

Redox-dependent processes influence most cellular functions, such as differentiation,
proliferation, and apoptosis. Mitochondria are at the center of these processes, as …

Significance: Eryptosis, the suicidal erythrocyte death, is characterized by cell shrinkage,
membrane blebbing, and phosphatidylserine translocation to the outer membrane leaflet …

Significance: Oxidative stress provokes the peroxidation of polyunsaturated fatty acids in
cellular membranes, leading to the formation of aldheydes that, due to their high chemical …

Red blood cells (RBC) are specifically differentiated to transport oxygen and carbon dioxide
in the blood and they lack most organelles, including mitochondria. The autoxidation of …

An imbalance between free radical generation and radical scavenging antioxidant systems
results in oxidative stress, which has been associated with cell injury observed in many age …

Red blood cells (RBCs) are exposed to both external and internal sources of oxidants that
challenge their integrity and compromise their physiological function and supply of oxygen …

The role of peroxiredoxin-2 (PRDX2) in preventing hydrogen peroxide-induced oxidative
stress in the red blood cell was investigated by comparing blood from PRDX2 knockout mice …

Abstract Superoxide dismutase 1 (SOD1) is an important antioxidative enzyme that protects
skin from oxidative stress. SOD1−/− mice with a genetic background of b129Sv mice showed …

The kidneys and the blood system mutually exert influence in maintaining homeostasis in
the body. Because the kidneys control erythropoiesis by producing erythropoietin and by …