State-of-the-art dermatophyte infections: epidemiology aspects, pathophysiology, and resistance mechanisms

NM Martinez-Rossi, NTA Peres, TA Bitencourt… - Journal of Fungi, 2021 - mdpi.com
The burden of fungal infections is not widely appreciated. Although these infections are
responsible for over one million deaths annually, it is estimated that one billion people are …

An update on the myriad antifungal resistance mechanisms in dermatophytes and the place of experimental and existential therapeutic agents for Trichophyton …

K Sardana, S Sharath, A Khurana… - Expert Review of Anti …, 2023 - Taylor & Francis
Introduction There is an epidemic emergence of increased resistance in dermatophytes with
to antifungal drugs with ergosterol1 (Erg1) and Erg11 mutations to terbinafine and azoles …

[PDF][PDF] Main Phenotypic Virulence Factors Identified in Trichophyton rubrum

E Martínez-Herrera, G Moreno-Coutiño… - J. Biol. Regul …, 2023 - researchgate.net
Background: Trichophyton rubrum (T. rubrum) is the most common etiological agent of
human dermatophytosis worldwide. T. rubrum has various phenotypic virulence factors that …

Rapid and sustained T cell-based immunotherapy against invasive fungal disease via a combined two step procedure

S Tischer-Zimmermann, E Salzer, T Bitencourt… - Frontiers in …, 2023 - frontiersin.org
Introduction Aspergillus fumigatus (Asp) infections constitute a major cause of morbidity and
mortality in patients following allogeneic hematopoietic stem cell transplantation (HSCT). In …

Alternative Splicing in Trichophyton rubrum Occurs in Efflux Pump Transcripts in Response to Antifungal Drugs

MER Lopes, TA Bitencourt, PR Sanches, MP Martins… - Journal of Fungi, 2022 - mdpi.com
Dermatophytes are challenging to treat because they have developed many strategies to
neutralize the stress triggered by antifungals. Drug tolerance is achieved by mechanisms …

The StuA Transcription Factor and Alternative Splicing Mechanisms Drive the Levels of MAPK Hog1 Transcripts in the Dermatophyte Trichophyton rubrum

L Martins-Santana, MF Petrucelli, PR Sanches… - Mycopathologia, 2024 - Springer
Trichophyton rubrum is a human fungal pathogen that causes dermatophytosis, an infection
that affects keratinized tissues. Integrated molecular signals coordinate mechanisms that …

The Transcription Factor StuA Regulates the Glyoxylate Cycle in the Dermatophyte Trichophyton rubrum under Carbon Starvation

MF Petrucelli, L Martins-Santana, PR Sanches… - International Journal of …, 2023 - mdpi.com
Trichophyton rubrum is the primary causative agent of dermatophytosis worldwide. This
fungus colonizes keratinized tissues and uses keratin as a nutritional source during …

PdStuA Is a Key Transcription Factor Controlling Sporulation, Hydrophobicity, and Stress Tolerance in Penicillium digitatum

Y Du, J Zhu, Z Tian, C Long - Journal of Fungi, 2023 - mdpi.com
Penicillium digitatum has become one of the main pathogens in citrus due to its high spore
production and easy spread. In this study, the function of the APSES transcription factor StuA …

Peptidase Regulation in Trichophyton rubrum Is Mediated by the Synergism Between Alternative Splicing and StuA-Dependent Transcriptional Mechanisms

L Martins-Santana, MF Petrucelli, PR Sanches… - Frontiers in …, 2022 - frontiersin.org
Trichophyton rubrum is the most common causative agent of dermatophytosis worldwide
and uses keratinized substrates such as skin and nails as its main source of nutrition during …

Identification and In Silico Analysis of Interaction of Active Compounds in Pimpinella anisum with Trichophyton rubrum Aspartate-B-Semialdehyde Dehydrogenase …

A KANIMOZHI, V ARANGANATHAN… - Indian Journal of …, 2024 - search.ebscohost.com
Trichophyton rubrum is the major causative organism of dermatophytosis. The methanolic
extracts of Pimpinella anisum seed has shown in vitro anti-dermatophytic activity. In the …