Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

NHE3 is the brush-border (BB) Na+/H+ exchanger of small intestine, colon, and renal
proximal tubule which is involved in large amounts of neutral Na+ absorption. NHE3 is a …

Dopamine is an important regulator of systemic blood pressure via multiple mechanisms. It
affects fluid and electrolyte balance by its actions on renal hemodynamics and epithelial ion …

Dopamine plays an important role in the pathogenesis of hypertension by regulating
epithelial sodium transport, vascular smooth muscle contractility and production of reactive …

Complex interactions between genes and environment result in a sodium-induced elevation
in blood pressure (salt sensitivity) and/or hypertension that lead to significant morbidity and …

Essential hypertension, which affects 25% of the middle-aged adult population, constitutes a
major risk factor for stroke, myocardial infarction, and heart and kidney failure. 1 The kidney …

The regulation of proximal tubular salt transport in hyperte... : Current Opinion in Nephrology and
Hypertension The regulation of proximal tubular salt transport in hypertension: an update …

Significance: The kidney plays an important role in the long-term control of blood pressure.
Oxidative stress is one of the fundamental mechanisms responsible for the development of …

Dopamine D3 receptors (D3R) modulate neuronal activity in several brain regions including
cortex, striatum, cerebellum, and hippocampus. A growing body of evidence suggests that …

Systemic arterial hypertension is one of the leading causes of morbidity and mortality in the
general population, being a risk factor for many cardiovascular diseases. Although its …