Deubiquitinases: From mechanisms to their inhibition by small molecules
Deubiquitinases (DUBs) are specialized proteases that remove ubiquitin from substrates or
cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in …
cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in …
Progress and challenges in targeting the SARS-CoV-2 papain-like protease
SARS-CoV-2 is the causative agent of the COVID-19 pandemic. The approval of vaccines
and small-molecule antivirals is vital in combating the pandemic. The viral polymerase …
and small-molecule antivirals is vital in combating the pandemic. The viral polymerase …
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
The papain-like protease PLpro is an essential coronavirus enzyme that is required for
processing viral polyproteins to generate a functional replicase complex and enable viral …
processing viral polyproteins to generate a functional replicase complex and enable viral …
Drug targets for corona virus: A systematic review
M Prajapat, P Sarma, N Shekhar, P Avti… - Indian journal of …, 2020 - journals.lww.com
Abstract The 2019-novel coronavirus (nCoV) is a major source of disaster in the 21 th
century. However, the lack of specific drugs to prevent/treat an attack is a major need at this …
century. However, the lack of specific drugs to prevent/treat an attack is a major need at this …
The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery
SARS-CoV-2 is the pathogen responsible for the COVID-19 pandemic. The SARS-CoV-2
papain-like cysteine protease (PLpro) has been implicated in playing important roles in virus …
papain-like cysteine protease (PLpro) has been implicated in playing important roles in virus …
Design of SARS-CoV-2 PLpro inhibitors for COVID-19 antiviral therapy leveraging binding cooperativity
Antiviral agents that complement vaccination are urgently needed to end the COVID-19
pandemic. The SARS-CoV-2 papain-like protease (PLpro), one of only two essential …
pandemic. The SARS-CoV-2 papain-like protease (PLpro), one of only two essential …
Ubiquitination in the regulation of inflammatory cell death and cancer
The ubiquitin system is complex, multifaceted, and is crucial for the modulation of a vast
number of cellular processes. Ubiquitination is tightly regulated at different levels by a range …
number of cellular processes. Ubiquitination is tightly regulated at different levels by a range …
[HTML][HTML] Crystal structure of SARS-CoV-2 papain-like protease
X Gao, B Qin, P Chen, K Zhu, P Hou, JA Wojdyla… - … Pharmaceutica Sinica B, 2021 - Elsevier
The pandemic of coronavirus disease 2019 (COVID-19) is changing the world like never
before. This crisis is unlikely contained in the absence of effective therapeutics or vaccine …
before. This crisis is unlikely contained in the absence of effective therapeutics or vaccine …
Recent discovery and development of inhibitors targeting coronaviruses
T Pillaiyar, S Meenakshisundaram, M Manickam - Drug discovery today, 2020 - Elsevier
Human coronaviruses (CoVs) are enveloped viruses with a positive-sense single-stranded
RNA genome. Currently, six human CoVs have been reported including human coronavirus …
RNA genome. Currently, six human CoVs have been reported including human coronavirus …
Drug development and medicinal chemistry efforts toward SARS‐coronavirus and Covid‐19 therapeutics
AK Ghosh, M Brindisi, D Shahabi… - …, 2020 - Wiley Online Library
The COVID‐19 pandemic caused by SARS‐CoV‐2 infection is spreading at an alarming
rate and has created an unprecedented health emergency around the globe. There is no …
rate and has created an unprecedented health emergency around the globe. There is no …