miRNAs as Cornerstones in Chronic Lymphocytic Leukemia Pathogenesis and Therapeutic Resistance–An emphasis on the interaction of signaling pathways
Chronic lymphocytic leukemia (CLL) accounts for the vast majority of cases of leukemia.
Patients of advanced age are more likely to develop the condition, which has a highly varied …
Patients of advanced age are more likely to develop the condition, which has a highly varied …
MicroRNAs in development and disease
D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …
introduced an additional level of intricacy to our understanding of gene regulation. There are …
Causes and consequences of microRNA dysregulation in cancer
CM Croce - Nature reviews genetics, 2009 - nature.com
Over the past several years it has become clear that alterations in the expression of
microRNA (miRNA) genes contribute to the pathogenesis of most—if not all—human …
microRNA (miRNA) genes contribute to the pathogenesis of most—if not all—human …
MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy
AL Kasinski, FJ Slack - Nature Reviews Cancer, 2011 - nature.com
In normal cells multiple microRNAs (miRNAs) converge to maintain a proper balance of
various processes, including proliferation, differentiation and cell death. miRNA …
various processes, including proliferation, differentiation and cell death. miRNA …
Targeting microRNAs in cancer: rationale, strategies and challenges
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that regulate
gene expression. Early studies have shown that miRNA expression is deregulated in cancer …
gene expression. Early studies have shown that miRNA expression is deregulated in cancer …
Physiological and pathological roles for microRNAs in the immune system
Mammalian microRNAs (miRNAs) have recently been identified as important regulators of
gene expression, and they function by repressing specific target genes at the post …
gene expression, and they function by repressing specific target genes at the post …
MicroRNAs in cancer
MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development,
cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is …
cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is …
MicroRNAs in cancer
Within the past few years, studies on microRNA (miRNA) and cancer have burst onto the
scene. Profiling of the miRNome (global miRNA expression levels) has become prevalent …
scene. Profiling of the miRNome (global miRNA expression levels) has become prevalent …
MicroRNAs in cancer: small molecules with a huge impact
Every cellular process is likely to be regulated by microRNAs, and an aberrant microRNA
expression signature is a hallmark of several diseases, including cancer. MicroRNA …
expression signature is a hallmark of several diseases, including cancer. MicroRNA …
miR-34a repression of SIRT1 regulates apoptosis
M Yamakuchi, M Ferlito… - Proceedings of the …, 2008 - National Acad Sciences
MicroRNA 34a (miR-34a) is a tumor suppressor gene, but how it regulates cell proliferation
is not completely understood. We now show that the microRNA miR-34a regulates silent …
is not completely understood. We now show that the microRNA miR-34a regulates silent …