miRNAs as Cornerstones in Chronic Lymphocytic Leukemia Pathogenesis and Therapeutic Resistance–An emphasis on the interaction of signaling pathways

AS Doghish, AI Abulsoud, SS Elshaer… - … -Research and Practice, 2023 - Elsevier
Chronic lymphocytic leukemia (CLL) accounts for the vast majority of cases of leukemia.
Patients of advanced age are more likely to develop the condition, which has a highly varied …

MicroRNAs in development and disease

D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

Causes and consequences of microRNA dysregulation in cancer

CM Croce - Nature reviews genetics, 2009 - nature.com
Over the past several years it has become clear that alterations in the expression of
microRNA (miRNA) genes contribute to the pathogenesis of most—if not all—human …

MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy

AL Kasinski, FJ Slack - Nature Reviews Cancer, 2011 - nature.com
In normal cells multiple microRNAs (miRNAs) converge to maintain a proper balance of
various processes, including proliferation, differentiation and cell death. miRNA …

Targeting microRNAs in cancer: rationale, strategies and challenges

R Garzon, G Marcucci, CM Croce - Nature reviews Drug discovery, 2010 - nature.com
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that regulate
gene expression. Early studies have shown that miRNA expression is deregulated in cancer …

Physiological and pathological roles for microRNAs in the immune system

RM O'connell, DS Rao, AA Chaudhuri… - Nature Reviews …, 2010 - nature.com
Mammalian microRNAs (miRNAs) have recently been identified as important regulators of
gene expression, and they function by repressing specific target genes at the post …

MicroRNAs in cancer

R Garzon, GA Calin, CM Croce - Annual review of medicine, 2009 - annualreviews.org
MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development,
cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is …

MicroRNAs in cancer

YS Lee, A Dutta - Annual Review of Pathology: Mechanisms of …, 2009 - annualreviews.org
Within the past few years, studies on microRNA (miRNA) and cancer have burst onto the
scene. Profiling of the miRNome (global miRNA expression levels) has become prevalent …

MicroRNAs in cancer: small molecules with a huge impact

MV Iorio, CM Croce - Journal of clinical oncology, 2009 - ascopubs.org
Every cellular process is likely to be regulated by microRNAs, and an aberrant microRNA
expression signature is a hallmark of several diseases, including cancer. MicroRNA …

miR-34a repression of SIRT1 regulates apoptosis

M Yamakuchi, M Ferlito… - Proceedings of the …, 2008 - National Acad Sciences
MicroRNA 34a (miR-34a) is a tumor suppressor gene, but how it regulates cell proliferation
is not completely understood. We now show that the microRNA miR-34a regulates silent …