The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

Eukaryotic cells are intracellularly divided into numerous compartments or organelles, which
coordinate specific molecules and biological reactions. Membrane‐bound organelles are …

The tumor suppressor protein p53 is inactivated in the majority of human cancers and
remains a prime target for developing new drugs to reactivate its tumor suppressing activity …

The p53 protein has appropriately been named the “guardian of the genome”. In almost all
human cancers, the powerful tumor suppressor function of p53 is compromised by a variety …

Referred to as the “guardian of the genome”, p53 is the most frequently mutated protein in
cancer and almost all cancers exhibit malfunction along the p53 pathway. As an …

Inhibition of the MDM2/X-p53 interaction is recognized as a potential anti-cancer strategy,
including the treatment of glioblastoma (GB). In response to cellular stressors, such as DNA …

Cancer is a leading cause of death worldwide. Targeted therapies aimed at key oncogenic
driver mutations in combination with chemotherapy and radiotherapy as well as …

In recent years, an increasing number of long non‑coding RNAs (lncRNAs) have been
discovered using microarrays and nucleic acid sequencing technology. LncRNAs exert …

The p53 protein, encoded by the TP53 gene, serves as a critical tumor suppressor, playing a
vital role in maintaining genomic stability and regulating cellular responses to stress …

Biomolecule misfolding and aggregation play a major role in human disease, spanning from
neurodegeneration to cancer. Inhibition of these processes is of considerable interest, and …