Current treatments and new possible complementary therapies for epithelial ovarian cancer
MP Garrido, AN Fredes, L Lobos-González… - Biomedicines, 2021 - mdpi.com
Epithelial ovarian cancer (EOC) is one of the deadliest gynaecological malignancies. The
late diagnosis is frequent due to the absence of specific symptomatology and the molecular …
late diagnosis is frequent due to the absence of specific symptomatology and the molecular …
Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma
The morbidity associated with pediatric medulloblastoma, in particular in patients who
develop leptomeningeal metastases, remains high in the absence of effective therapies …
develop leptomeningeal metastases, remains high in the absence of effective therapies …
The current landscape of targeted clinical trials in non-WNT/non-SHH medulloblastoma
DR Ghasemi, G Fleischhack, T Milde, KW Pajtler - Cancers, 2022 - mdpi.com
Simple Summary Medulloblastoma is a form of malignant brain tumor that arises
predominantly in infants and young children and can be divided into different groups based …
predominantly in infants and young children and can be divided into different groups based …
Combination of PARP and WEE1 inhibitors in vitro: Potential for use in the treatment of SHH medulloblastoma
M Lukoseviciute, A Theodosopoulou… - Oncology …, 2023 - spandidos-publications.com
Medulloblastoma (MB), grouped as either WNT‑activated, Sonic hedgehog (SHH)‑activated,
or non-WNT/non-SHH group 3, accounts for almost 20% of all childhood brain cancers. In …
or non-WNT/non-SHH group 3, accounts for almost 20% of all childhood brain cancers. In …
[HTML][HTML] Inhibition of STAT3: A promising approach to enhancing the efficacy of chemotherapy in medulloblastoma
Medulloblastoma is a type of brain cancer that primarily affects children. While
chemotherapy has been shown to be effective in treating medulloblastoma, the development …
chemotherapy has been shown to be effective in treating medulloblastoma, the development …
The Role of PARP Inhibitors in Patients with Primary Malignant Central Nervous System Tumors
SE Gueble, JC Vasquez, RS Bindra - Current Treatment Options in …, 2022 - Springer
Opinion statement Primary malignant central nervous (CNS) tumors are a devastating group
of diseases with urgent need for improved treatment options. Surgery, radiation, and …
of diseases with urgent need for improved treatment options. Surgery, radiation, and …
The pivotal role of irradiation‐induced apoptosis in the pathogenesis and therapy of medulloblastoma
SA Richard - Cancer Reports, 2024 - Wiley Online Library
Background Medulloblastoma (MB) is a rare primitive neuroectodermal tumors originating
from the cerebellum. MB is the most common malignant primary brain tumor of childhood …
from the cerebellum. MB is the most common malignant primary brain tumor of childhood …
BRCA2 deficiency increases sensitivity of medulloblastoma to Olaparib by inhibiting RAD51-mediated DNA damage repair system
J Yu, C Zhang, W Shi, H Rui, H Li - Clinical and Translational Oncology, 2022 - Springer
Purpose BRCA2 defect exists in glioma and regulates drug resistance of glioma to
chemotherapy. However, its role in medulloblastoma and the mechanism is not known. To …
chemotherapy. However, its role in medulloblastoma and the mechanism is not known. To …
Profiling epithelial viral receptor expression in amniotic membrane and nasal epithelial cells at birth
B Renouf, EN Sutanto, C Kidd, J Lim, M Amin, L Berry… - 2024 - researchsquare.com
Children with wheeze and asthma present with airway epithelial vulnerabilities, such as
impaired responses to viral infection. It is postulated that the in utero environment may …
impaired responses to viral infection. It is postulated that the in utero environment may …
Radioresistance and radiosensitization in high-risk Group 3 pediatric medulloblastoma
E Hawkins - 2023 - theses.hal.science
Medulloblastoma (MB) is the most common pediatric malignant brain tumour, and is treated
with a multimodal regimen of surgical resection, chemotherapy, and radiotherapy …
with a multimodal regimen of surgical resection, chemotherapy, and radiotherapy …