Current treatments and new possible complementary therapies for epithelial ovarian cancer

MP Garrido, AN Fredes, L Lobos-González… - Biomedicines, 2021 - mdpi.com
Epithelial ovarian cancer (EOC) is one of the deadliest gynaecological malignancies. The
late diagnosis is frequent due to the absence of specific symptomatology and the molecular …

Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma

M Khang, JH Lee, T Lee, HW Suh, S Lee… - Science translational …, 2023 - science.org
The morbidity associated with pediatric medulloblastoma, in particular in patients who
develop leptomeningeal metastases, remains high in the absence of effective therapies …

The current landscape of targeted clinical trials in non-WNT/non-SHH medulloblastoma

DR Ghasemi, G Fleischhack, T Milde, KW Pajtler - Cancers, 2022 - mdpi.com
Simple Summary Medulloblastoma is a form of malignant brain tumor that arises
predominantly in infants and young children and can be divided into different groups based …

Combination of PARP and WEE1 inhibitors in vitro: Potential for use in the treatment of SHH medulloblastoma

M Lukoseviciute, A Theodosopoulou… - Oncology …, 2023 - spandidos-publications.com
Medulloblastoma (MB), grouped as either WNT‑activated, Sonic hedgehog (SHH)‑activated,
or non-WNT/non-SHH group 3, accounts for almost 20% of all childhood brain cancers. In …

[HTML][HTML] Inhibition of STAT3: A promising approach to enhancing the efficacy of chemotherapy in medulloblastoma

S Kumar, DA Arwind, H Kumar, S Pandey, R Nayak… - Translational …, 2024 - Elsevier
Medulloblastoma is a type of brain cancer that primarily affects children. While
chemotherapy has been shown to be effective in treating medulloblastoma, the development …

The Role of PARP Inhibitors in Patients with Primary Malignant Central Nervous System Tumors

SE Gueble, JC Vasquez, RS Bindra - Current Treatment Options in …, 2022 - Springer
Opinion statement Primary malignant central nervous (CNS) tumors are a devastating group
of diseases with urgent need for improved treatment options. Surgery, radiation, and …

The pivotal role of irradiation‐induced apoptosis in the pathogenesis and therapy of medulloblastoma

SA Richard - Cancer Reports, 2024 - Wiley Online Library
Background Medulloblastoma (MB) is a rare primitive neuroectodermal tumors originating
from the cerebellum. MB is the most common malignant primary brain tumor of childhood …

BRCA2 deficiency increases sensitivity of medulloblastoma to Olaparib by inhibiting RAD51-mediated DNA damage repair system

J Yu, C Zhang, W Shi, H Rui, H Li - Clinical and Translational Oncology, 2022 - Springer
Purpose BRCA2 defect exists in glioma and regulates drug resistance of glioma to
chemotherapy. However, its role in medulloblastoma and the mechanism is not known. To …

Profiling epithelial viral receptor expression in amniotic membrane and nasal epithelial cells at birth

B Renouf, EN Sutanto, C Kidd, J Lim, M Amin, L Berry… - 2024 - researchsquare.com
Children with wheeze and asthma present with airway epithelial vulnerabilities, such as
impaired responses to viral infection. It is postulated that the in utero environment may …

Radioresistance and radiosensitization in high-risk Group 3 pediatric medulloblastoma

E Hawkins - 2023 - theses.hal.science
Medulloblastoma (MB) is the most common pediatric malignant brain tumour, and is treated
with a multimodal regimen of surgical resection, chemotherapy, and radiotherapy …