The Notch signaling pathway plays an essential role in a wide variety of biological
processes including cell fate determination of vascular endothelial cells and the regulation …

Cancer stem-like cells (CSCs), a subpopulation of cancer cells, possess remarkable
capability in proliferation, self-renewal, and differentiation. Their presence is recognized as a …

Ovarian cancer has become the largest cause of gynaecological cancer-related mortality. It
is typically diagnosed at a late stage and has no effective screening strategy. Ovarian cancer …

Desmoid tumors (DTs) are rare soft tissue mesenchymal neoplasms that may be associated
with impairments, disfigurement, morbidity, and (rarely) mortality. DT disease course can be …

Desmoid tumor (DT) is a rare, soft tissue neoplasm associated with an unpredictable clinical
course. Although lacking metastatic potential, DT is often locally aggressive and invasive …

We here defined the impacts of γ-secretase inhibitors (GSIs) on T-cell-dependent BCMA-
specific multiple myeloma (MM) cell lysis and immunomodulatory effects induced by …

The mechanism of tumor drug resistance is complex and may involve stem cell
maintenance, epithelial-mesenchymal transition, the activation of survival signaling …

Synthetic receptors targeted to the secretory pathway often fail to exhibit the expected
activity due to post-translational modifications (PTMs) and/or improper folding. Here, we …

Two phase-III clinical trials with anti-amyloid peptide antibodies have met their primary goal,
ie slowing of Alzheimer's disease (AD) progression. However, antibody therapy may not be …

Abstract Jagged1 (JAG1) is a Notch ligand that correlates with tumor progression. Not
limited to its function as a ligand, JAG1 can be cleaved, and its intracellular domain …