The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …

Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …

Mammalian cells take up extracellular material by a variety of different mechanisms that are
collectively termed endocytosis. Endocytic mechanisms serve many important cellular …

▪ Abstract Endocytosis in eukaryotic cells is characterized by the continuous and regulated
formation of prolific numbers of membrane vesicles at the plasma membrane. These …

We have used RNA interference to knock down the AP-2 μ2 subunit and clathrin heavy
chain to undetectable levels in HeLaM cells. Clathrin-coated pits associated with the plasma …

Hermansky-Pudlak syndrome (HPS) is a genetic disorder characterized by defective
lysosome-related organelles. Here, we report the identification of two HPS patients with …

Clathrin-coated vesicles were the first discovered and remain the most extensively
characterized transport vesicles. They mediate endocytosis of transmembrane receptors and …

▪ Abstract There has recently been considerable progress in understanding the regulation of
clathrin-coated vesicle (CCV) formation and function. These advances are due to the …

Exosomes are extracellular vesicles that are released when endosomes fuse with the
plasma membrane. They have been implicated in various functions in both health and …

Two new adaptor-related protein complexes, AP-3 and AP-4, have recently been identified,
and both have been implicated in protein sorting at the trans-Golgi network (TGN) and/or …