CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease
JFC Glatz, LC Heather… - Physiological reviews, 2024 - journals.physiology.org
The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …
Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer
Metabolism alterations are hallmarks of cancer, but the involvement of lipid metabolism in
disease progression is unclear. We investigated the role of lipid metabolism in prostate …
disease progression is unclear. We investigated the role of lipid metabolism in prostate …
CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression
AR Terry, V Nogueira, H Rho, G Ramakrishnan, J Li… - Cell Metabolism, 2023 - cell.com
A high-fat diet (HFD) promotes metastasis through increased uptake of saturated fatty acids
(SFAs). The fatty acid transporter CD36 has been implicated in this process, but a detailed …
(SFAs). The fatty acid transporter CD36 has been implicated in this process, but a detailed …
Hepatocyte-specific disruption of CD36 attenuates fatty liver and improves insulin sensitivity in HFD-fed mice
CG Wilson, JL Tran, DM Erion, NB Vera… - …, 2016 - academic.oup.com
CD36/FAT (fatty acid translocase) is associated with human and murine nonalcoholic fatty
liver disease, but it has been unclear whether it is simply a marker or whether it directly …
liver disease, but it has been unclear whether it is simply a marker or whether it directly …
[HTML][HTML] CD36-mediated metabolic rewiring of breast cancer cells promotes resistance to HER2-targeted therapies
Although it is established that fatty acid (FA) synthesis supports anabolic growth in cancer,
the role of exogenous FA uptake remains elusive. Here we show that, during acquisition of …
the role of exogenous FA uptake remains elusive. Here we show that, during acquisition of …
Metabolism in cardiomyopathy: every substrate matters
J Ritterhoff, R Tian - Cardiovascular research, 2017 - academic.oup.com
Cardiac metabolism is highly adaptive to changes in fuel availability and the energy demand
of the heart. This metabolic flexibility is key for the heart to maintain its output during the …
of the heart. This metabolic flexibility is key for the heart to maintain its output during the …
The role of CD36 in cardiovascular disease
H Shu, Y Peng, W Hang, J Nie, N Zhou… - Cardiovascular …, 2022 - academic.oup.com
CD36, also known as the scavenger receptor B2, is a multifunctional receptor widely
expressed in various organs. CD36 plays a crucial role in the uptake of long-chain fatty …
expressed in various organs. CD36 plays a crucial role in the uptake of long-chain fatty …
CD36 in chronic kidney disease: novel insights and therapeutic opportunities
CD36 (also known as scavenger receptor B2) is a multifunctional receptor that mediates the
binding and cellular uptake of long-chain fatty acids, oxidized lipids and phospholipids …
binding and cellular uptake of long-chain fatty acids, oxidized lipids and phospholipids …
[HTML][HTML] Abnormalities of glucose and lipid metabolism in myocardial ischemia-reperfusion injury
H Tian, X Zhao, Y Zhang, Z Xia - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Myocardial ischemia-reperfusion injury is a common condition in cardiovascular diseases,
and the mechanism of its occurrence involves multiple complex metabolic pathways and …
and the mechanism of its occurrence involves multiple complex metabolic pathways and …