DUSPs (dual-specificity phosphatases) are a heterogeneous group of protein phosphatases
that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine …

There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as
negative regulators of MAPK activity in mammalian cells and these can be subdivided into …

The TIGAR protein has antioxidant activity that supports intestinal tissue repair and
adenoma development. Using a pancreatic ductal adenocarcinoma (PDAC) model, we …

Mitogen‐activated protein (MAP) kinases are important players in signal transduction
pathways activated by a range of stimuli and mediate a number of physiological and …

The mitogen-activated protein kinases (MAPKs) are key regulators of cell growth and
survival in physiological and pathological processes. Aberrant MAPK signaling plays a …

Abstract The RAS-RAF-MEK-extracellular signal-regulated kinase (ERK) pathway plays a
pivotal role in various cellular responses, including cellular growth, differentiation, survival …

Mitogen-activated protein kinase (MAPK) pathway signaling plays an important role in the
majority of non-small-cell lung cancers (NSCLCs). In a prior microarray analysis of …

We previously found frequent loss of heterozygosity at 12q21 and 12q22-q23. 1 in primary
pancreatic cancers, and the DUSP6/MKP-3 gene residing in this region at 12q22 lost its …

Dual-specificity protein tyrosine phosphatases are a burgeoning family of enzymes, some of
which, the MKPs, are implicated in the regulation of mitogen-activated protein (MAP) …

Mitogen-activated protein kinase (MAPK) phosphatases (MKPs) negatively regulate MAPK
activity. In the present study, we have identified a novel MKP, designated MKP-7, and …