Aminoglycosides are commonly prescribed antibiotics with deleterious side effects to the
inner ear. Due to their popular application as a result of their potent antimicrobial activities …

Purpose The platinum chemotherapy agents cisplatin and carboplatin are widely used in the
treatment of adult and pediatric cancers. Cisplatin causes hearing loss in at least 60% of …

Programmed cell death (PCD)—apoptosis, autophagy and programmed necrosis—is any
pathological form of cell death mediated by intracellular processes. Ototoxic drugs, ageing …

Oxygen metabolism in the mitochondria is essential for biological activity, and reactive
oxygen species (ROS) are produced simultaneously in the cell. Once an imbalance between …

Reactive oxygen species (ROS) production is involved in several apoptotic and necrotic cell
death pathways in auditory tissues. These pathways are the major causes of most types of …

Aminoglycosides (AG) are commonly prescribed antibiotics with potent bactericidal
activities. One main side effect is permanent sensorineural hearing loss, induced by …

The mechanisms of sensory hair cell degeneration in response to different ototoxic stimuli
share a final common pathway: caspase activation. Inhibition of caspases prevents or delays …

Regeneration of sensory hair cells in the mature avian inner ear was first described just over
20 years ago. Since then, it has been shown that many other non-mammalian species either …

Inner ear sensory hair cell death is observed in the majority of hearing and balance
disorders, affecting the health of more than 600 million people worldwide. While normal …

One of the causes of sensorineural hearing loss is the loss of auditory hair cells following
exposure to environmental stresses. Auditory hair cell death in response to cochlear trauma …