The skeleton is an exquisitely sensitive and archetypal T3-target tissue that demonstrates
the critical role for thyroid hormones during development, linear growth, and adult bone …

Articular cartilage is a connective tissue consisting of a specialized extracellular matrix
(ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are …

Background: Knee osteoarthritis (KOA) is one of the most common chronic musculoskeletal
disorders worldwide, for which exosomes derived from stem cells may provide an effective …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Objective Osteoarthritis (OA) is the most prevalent joint disease. As disease-modifying
therapies are not available, novel therapeutic targets need to be discovered and prioritized …

Osteoarthritis (OA) was once defined as a non-inflammatory arthropathy, but it is now well-
recognized that there is a major inflammatory component to this disease. In addition to …

Osteoarthritis has a highly negative impact on quality of life because of the associated pain
and loss of joint function. Here we describe the largest meta-analysis so far of osteoarthritis …

Increased vascular endothelial growth factor (VEGF) levels are associated with osteoarthritis
(OA) progression. Indeed, VEGF appears to be involved in OA‐specific pathologies …

Osteoarthritis is a chronic degenerative disorder of the joint and represents one of the most
common diseases worldwide. Its prevalence and severity are increasing owing to aging of …

The aim of this study was to identify inflammatory mediators of potential clinical relevance in
synovial fluid (SF) samples of patients with knee osteoarthritis (OA). Therefore, radiographic …