The complement system is an evolutionary old and crucial component of innate immunity,
which is key to the detection and removal of invading pathogens. It was initially discovered …

Malaria is a devastating infection caused by protozoa of the genus Plasmodium. Drug
resistance is widespread, no new chemical class of antimalarials has been introduced into …

Malaria parasites exhibit a complex lifecycle, requiring extensive asexual replication in the
liver and blood of the vertebrate host, and in the haemocoel of the insect vector. Yet, they …

Malaria infections of mammals are initiated by the transmission of Plasmodium salivary
gland sporozoites during an Anopheles mosquito vector bite. Sporozoites make their way …

Apicomplexan parasites possess secretory organelles called rhoptries that undergo
regulated exocytosis upon contact with the host. This process is essential for the parasitic …

Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple
selection pressures. The host environment changes dramatically in severe malaria, but the …

IP 3-dependent Ca 2+ signaling controls a myriad of cellular processes in higher eukaryotes
and similar signaling pathways are evolutionarily conserved in Plasmodium, the intracellular …

Malaria parasites complete their intra-erythrocytic developmental cycle (IDC) in multiples of
24 h suggesting a circadian basis, but the mechanism controlling this periodicity is unknown …

Plasmodium falciparum stage V gametocytes are responsible for parasite transmission, and
drugs targeting this stage are needed to support malaria elimination. We here screen the …

Pathogens exploit multiple cellular and molecular pathways in the host organisms for their
entry, survival and dissemination. The cell surface receptors such as G protein-coupled …