Roles of HMGA proteins in cancer

A Fusco, M Fedele - Nature Reviews Cancer, 2007 - nature.com
The high mobility group A (HMGA) non-histone chromatin proteins alter chromatin structure
and thereby regulate the transcription of several genes by either enhancing or suppressing …

[HTML][HTML] Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer

R Sgarra, A Rustighi, MA Tessari, J Di Bernardo… - FEBS letters, 2004 - Elsevier
The structural characteristics of the three nuclear phosphoproteins of the high mobility group
A family are outlined and related to their participation in chromatin structure alteration in …

HMGA1 in cancer: Cancer classification by location

Y Wang, L Hu, Y Zheng, L Guo - Journal of Cellular and …, 2019 - Wiley Online Library
The high mobility group A1 (HMGA1) gene plays an important role in numerous malignant
cancers. HMGA1 is an oncofoetal gene, and we have a certain understanding of the …

High mobility group a proteins as tumor markers

P Pallante, R Sepe, F Puca, A Fusco - Frontiers in medicine, 2015 - frontiersin.org
Almost 30 years ago, overexpression of HMGA proteins was associated with malignant
phenotype of rat thyroid cells transformed with murine retroviruses. Thereafter, several …

Increased expression of high mobility group A proteins in lung cancer

VK Sarhadi, H Wikman, K Salmenkivi… - The Journal of …, 2006 - Wiley Online Library
High mobility group A (HMGA) proteins play an important role in the regulation of
transcription, differentiation, and neoplastic transformation. In this work, the expression of …

HMGA and cancer

M Fedele, A Fusco - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2010 - Elsevier
Long-standing studies have clearly established that the architectural chromatinic proteins
High Mobility Group A (HMGA) are among the most widely expressed cancer-associated …

Let-7a inhibits growth and migration of breast cancer cells by targeting HMGA1

K Liu, C Zhang, T Li, Y Ding, T Tu… - International …, 2015 - spandidos-publications.com
Let-7 is one of the earliest discovered microRNAs (miRNAs) and has been reported to
regulate self renewal and tumorigenicity of breast cancer cells. Let-7a is a member of this …

Comparative gene expression analysis of ovarian carcinoma and normal ovarian epithelium by serial analysis of gene expression

DG Peters, DM Kudla, JA DeLoia, TJ Chu… - … Biomarkers & Prevention, 2005 - AACR
Despite the poor prognosis of ovarian cancer and the importance of early diagnosis, there
are no reliable noninvasive biomarkers for detection in the early stages of disease …

HMGA1 and HMGA2 protein expression correlates with advanced tumour grade and lymph node metastasis in pancreatic adenocarcinoma

S Piscuoglio, I Zlobec, P Pallante, R Sepe… - …, 2012 - Wiley Online Library
Piscuoglio S, Zlobec I, Pallante P, Sepe R, Esposito F, Zimmermann A, Diamantis I,
Terracciano L, Fusco A & Karamitopoulou E (2012) Histopathology 60, 397–404 HMGA1 …

MYC-regulated pseudogene HMGA1P6 promotes ovarian cancer malignancy via augmenting the oncogenic HMGA1/2

X Tian, J Song, X Zhang, M Yan, S Wang, Y Wang… - Cell death & …, 2020 - nature.com
Pseudogenes have long been considered as nonfunctional genomic sequences. Recent
studies have shown that they can potentially regulate the expression of protein-coding …