Microorganisms within the gut and other niches may contribute to carcinogenesis, as well as
shaping cancer immunosurveillance and response to immunotherapy. Our understanding of …

Oral and esophageal squamous cell carcinomas harbor a diverse microbiome that differs
compositionally from precancerous and healthy tissues. Though causality is yet to be …

Transposable elements, known colloquially as 'jumping genes', constitute approximately
45% of the human genome. Cells utilize epigenetic defenses to limit transposable element …

Efforts to precisely identify tumor human leukocyte antigen (HLA) bound peptides capable of
mediating T cell-based tumor rejection still face important challenges. Recent studies …

The human genome contains a large number of retroviral elements acquired over the
process of evolution, some of which are specific to primates. However, as many of these are …

The virome is comprised of endogenous retroviruses, eukaryotic viruses, and
bacteriophages and is increasingly being recognized as an essential part of the human …

Transposable elements, including endogenous retroviruses (ERVs), comprise almost 45%
of the human genome. This could represent a significant pathogenic burden but it is …

In diseases where epigenetic mechanisms are changed, such as cancer, many genes show
altered gene expression and inhibited genes become activated. Human endogenous …

Abstract Background Human endogenous retroviruses (HERVs) occupy a substantial
fraction of the genome and impact cellular function with both beneficial and deleterious …

Stem cells are capable of unlimited proliferation but can be induced to form brain cells.
Factors that specifically regulate human development are poorly understood. We found that …