Calpains are evolutionarily conserved and widely expressed Ca 2+-activated cysteine
proteases that act at neutral pH. The activity of calpains is tightly regulated, given that their …

Neurodegenerative disorders represent a major and growing healthcare challenge globally.
Among the numerous molecular pathways implicated in their pathogenesis, calpain …

Ionotropic glutamate receptors (GluRs) are targets for modulation in Hebbian and
homeostatic synaptic plasticity and are remodeled by development, experience, and …

Calcium-dependent proteolytic calpains are implicated in a variety of physiological
processes, as well as pathologies associated with calcium overload. However, the …

Neuromuscular junctions are the synapses between motor neurons and skeletal muscle
fibers, which mediate voluntary muscle movement. Since neuromuscular junctions are also …

Cell to cell communication facilitates tissue development and physiology. Under
pathological conditions, brain tumors disrupt glia-neuron communication signals that in …

A new fate of cell surface receptors, cleaved activation in the nucleus, is summarized. The
intracellular domain (ICD) of cell surface receptors, cleaved by enzymes like γ-secretase …

Synapse development is coordinated by intercellular communication between the pre-and
postsynaptic compartments, and by neuronal activity itself. In flies as in vertebrates, neuronal …

Prolonged periods of forced social isolation is detrimental to well-being, yet we know little
about which genes regulate susceptibility to its effects. In the fruit fly, Drosophila …

Presynaptic glutamate receptors (GluRs) modulate neurotransmitter release and are
physiological targets for regulation during various forms of plasticity. Although much is …