Beads on a string—nucleosome array arrangements and folding of the chromatin fiber
Understanding how the genome is structurally organized as chromatin is essential for
understanding its function. Here, we review recent developments that allowed the …
understanding its function. Here, we review recent developments that allowed the …
[HTML][HTML] Fluid-like chromatin: Toward understanding the real chromatin organization present in the cell
Eukaryotic chromatin is a negatively charged polymer consisting of genomic DNA, histones,
and various nonhistone proteins. Because of its highly charged character, the structure of …
and various nonhistone proteins. Because of its highly charged character, the structure of …
[HTML][HTML] In vitro reconstitution of chromatin domains shows a role for nucleosome positioning in 3D genome organization
E Oberbeckmann, K Quililan, P Cramer… - Nature Genetics, 2024 - nature.com
Eukaryotic genomes are organized into chromatin domains. The molecular mechanisms
driving the formation of these domains are difficult to dissect in vivo and remain poorly …
driving the formation of these domains are difficult to dissect in vivo and remain poorly …
[HTML][HTML] Ultrastructural details of mammalian chromosome architecture
Over the past decade, 3C-related methods have provided remarkable insights into
chromosome folding in vivo. To overcome the limited resolution of prior studies, we extend a …
chromosome folding in vivo. To overcome the limited resolution of prior studies, we extend a …
[HTML][HTML] Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
Liquid–liquid phase separation (LLPS) is an important mechanism that helps explain the
membraneless compartmentalization of the nucleus. Because chromatin compaction and …
membraneless compartmentalization of the nucleus. Because chromatin compaction and …
[HTML][HTML] Histone dynamics mediate DNA unwrapping and sliding in nucleosomes
GA Armeev, AS Kniazeva, GA Komarova… - Nature …, 2021 - nature.com
Nucleosomes are elementary building blocks of chromatin in eukaryotes. They tightly
wrap∼ 147 DNA base pairs around an octamer of histone proteins. How nucleosome …
wrap∼ 147 DNA base pairs around an octamer of histone proteins. How nucleosome …
[HTML][HTML] Chromosome organization by one-sided and two-sided loop extrusion
SMC complexes, such as condensin or cohesin, organize chromatin throughout the cell
cycle by a process known as loop extrusion. SMC complexes reel in DNA, extruding and …
cycle by a process known as loop extrusion. SMC complexes reel in DNA, extruding and …
[HTML][HTML] Cohesin residency determines chromatin loop patterns
The organization of chromatin into higher order structures is essential for chromosome
segregation, the repair of DNA-damage, and the regulation of gene expression. Using Micro …
segregation, the repair of DNA-damage, and the regulation of gene expression. Using Micro …
[HTML][HTML] Multiscale modeling of genome organization with maximum entropy optimization
ABSTRACT Three-dimensional (3D) organization of the human genome plays an essential
role in all DNA-templated processes, including gene transcription, gene regulation, and …
role in all DNA-templated processes, including gene transcription, gene regulation, and …
Physical nature of chromatin in the nucleus
K Maeshima, S Iida, S Tamura - Cold Spring Harbor …, 2021 - cshperspectives.cshlp.org
Genomic information is encoded on long strands of DNA, which are folded into chromatin
and stored in a tiny nucleus. Nuclear chromatin is a negatively charged polymer composed …
and stored in a tiny nucleus. Nuclear chromatin is a negatively charged polymer composed …